Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Category：Pharmaceutical Materials
Introduction
Molecular Formula: C14H13NO4S Molecular Weight: 291.32 CAS Registry Number: 161798-01-2 Density: 1.3352- (3-aldehyde 4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid ethyl ester, also known as Ugi key intermediate, has the following properties and uses:
Name: Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
CAS: 161798-01-2
Appearance: yellowish powder
Assay: ≥99%
Capacity: 100mt/year
Min.package: 1gram
Application: Febuxostat intermediate
Standard: enterprise export
nature:
Appearance: White crystalline powder
Soluble: soluble in some organic solvents such as methanol, ethanol, and dimethylformamide
Stability: Stable, not easily decomposed
Purpose:
Manufacturing method:
Ethyl 2- (3-aldehyde-4-hydroxyphenyl) -4-methylthiazole-5-carboxylate can be synthesized through a multi-step reaction. A common method is to react 3-hydroxy-4-methylbenzaldehyde with ethyl methoxyacetic acid, methyl mercaptan, and dimethylformamide, and obtain the target product after acid catalysis and deprotection reaction.
Security information:
2- (3-aldehyde 4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid ethyl ester is a chemical with certain toxicity. Please pay attention to safety when using it.
When stored, it should be sealed and kept away from sources of fire and oxidants.
When preparing and using, relevant safety operating procedures and laboratory regulations should be followed, and personal protective equipment such as laboratory gloves and protective goggles should be used.
| Name | Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate |
| Synonyms | Febuxostat-23 5-carboxylato-1-ethyl-2-(3-forMyl-4-h Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-Thiazolecarboxylate Ethyl 2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-HYDROXYPHENYL)-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Thiazolecarboxylicacid,2-(3-forMyl-4-hydroxyphenyl)-4-Methyl-,ethylester 2-(3-Formyl-4-hydroxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester (2-(3-Formyl-4-hydroxy-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester |
| CAS | 161798-01-2 |
| EINECS | 692-179-2 |
| InChI | InChI=1/C14H13NO4S/c1-3-19-14(18)12-8(2)15-13(20-12)9-4-5-11(17)10(6-9)7-16/h4-7,17H,3H2,1-2H3 |
| Molecular Formula | C14H13NO4S |
| Molar Mass | 291.32 |
| Density | 1.335 |
| Melting Point | 116 °C |
| Boling Point | 446.7±55.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Pale Yellow to Yellow |
| pKa | 6.81±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.625 |
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