Eslicarbazepine acetate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID92645
CAS NO.236395-14-5
Purity 98%
MDL NumberMFCD06798333
Colecular formula C17H16N2O3
Molecular weight 296.321
Melting point: 183-185°C
Boiling point: 427.4°C at 760mmHg
| Category | Content |
|---|---|
| Generic Name | Eslicarbazepine Acetate |
| Brand Name | Aptiom, Zebinix, Exalief, Stedesa, Erelib, Pazzul, etc. |
| Chemical Formula | C17H16N2O3 |
| CAS Number | 236395-14-5 |
| Molecular Weight | 300.32 g/mol |
| Mechanism of Action | Eslicarbazepine acetate is a prodrug that is rapidly metabolized to its active metabolite, eslicarbazepine. It is thought to inhibit voltage-gated sodium channels, stabilizing the inactivated state and preventing neuronal firing. |
| Indications | Used as an adjunctive therapy for partial-onset seizures in adults. |
| Dosage Forms | Tablets (400 mg, 800 mg, 1200 mg) |
| Administration | – Taken orally once daily, with or without food.<br>- Initial dose: 400 mg once daily, increased to 800 mg after 1 week.<br>- Maximum dose: 1200 mg once daily. |
| Pharmacokinetics | – High bioavailability.<br>- Peak serum concentration reached 1-4 hours after dosing.<br>- Eliminated primarily via renal excretion.<br>- Half-life: 10-20 hours. |
| Side Effects | – Common: Dizziness, somnolence, headache, nausea.<br>- Serious: Increased heart rate, prolonged PR interval, suicidal thoughts. |
| Precautions | – Avoid abrupt discontinuation to prevent increased seizure frequency.<br>- Monitor for changes in behavior or suicidal thoughts.<br>- Use with caution in patients with renal impairment. |
| Storage | Store at room temperature, protect from moisture. |
| Developer | BIAL-Portela & Ca, S.A. |
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