Erythromycin Base CAS 114-07-8
Category：Active Pharmaceutical Ingredients
Introduction
Erythromycin is a commonly used macrolide antibiotic. It is mainly used in penicillin allergic patients, penicillin-resistant Staphylococcus aureus infection, streptococcus, pneumococcus infection and diphtheria carriers.
Molecular Formula：C37H67NO13
Molecular Weight: 733.94
CAS No.: 114-07-8
Description
Erythromycin is a white or slightly yellow powder or colourless or slightly yellow crystals, slightly hygroscopic. It is slightly soluble in water (the solubility decreases as the temperature rises), freely soluble in ethanol (96 per cent), soluble in methanol.
Application
Erythromycin is mainly used for staphylococcal infections resistant to penicillin. It can also be used for streptococcus, pneumococcal infections and diphtheria carriers. This product is a mixture, the main component is erythromycin A, and a small amount of erythromycin B and C. White or slightly yellow crystal or powder, odorless, bitter, alkaline, can form salts with inorganic or organic acids, and can also form esters. For example, tasteless erythromycin is the lauryl sulfate of erythromycin propionate. It has no bitter taste after oral administration, can resist acid and is not destroyed by gastric acid, and has good oral absorption. The indications are the same as erythromycin. The mechanism of action of erythromycin is to inhibit the synthesis of bacterial proteins and hinder the formation of long peptide chains to play an antibacterial effect. The antibacterial spectrum is similar to penicillin G, most of the strains resistant to penicillin are sensitive to this product, which is suitable for cases of drug resistance or allergy to penicillin. It is clinically effective for syphilis and gonorrhea.
Packing and Storage
Preserve in tight container.
Minimum Order
One package
Erythromycin Base: A Veterinary Antibiotic
Erythromycin Base is an important antibiotic in veterinary medicine, widely used for treating a variety of bacterial infections in animals.
1. General Characteristics
| Aspect | Details |
| Classification | Macrolide antibiotic |
| Source | Produced by Streptomyces erythreus. The base form is one of the common presentations of this antibiotic. |
| Formulation | Available as powders, which can be formulated into tablets, capsules, or oral suspensions for oral administration to animals. It can also be incorporated into topical ointments for treating skin infections. |
| Solubility | Sparingly soluble in water. This property affects its formulation and administration methods. Special techniques or carriers are often used to enhance its bioavailability in animals. |
2. Mechanism of Action
| Action | Explanation |
| Inhibition of Protein Synthesis | Erythromycin Base binds to the 50S ribosomal subunit of bacteria. It specifically blocks the exit tunnel of the growing polypeptide chain, preventing the elongation of the polypeptide. By inhibiting the movement of the ribosome along the mRNA, it effectively stops the addition of new amino acids to the growing protein chain, leading to the inhibition of bacterial protein synthesis and subsequent growth arrest. |
| Selective Activity | It has a mainly Gram – positive antibacterial spectrum. It is highly effective against bacteria such as Staphylococcus spp., Streptococcus spp., and Corynebacterium spp. It also shows some activity against certain Gram – negative bacteria, mycoplasmas, and chlamydiae. The unique binding site on the ribosome of these organisms allows erythromycin base to exert its antibacterial effect. |
3. Clinical Applications and Considerations
| Category | Details |
| Applications | – Treating respiratory tract infections in livestock and poultry. In poultry, it can be used against Mycoplasma gallisepticum and Staphylococcus aureus infections. In cattle, it helps combat respiratory diseases caused by Streptococcus spp. – Used to manage skin and soft – tissue infections in animals. Topical applications are effective against infections caused by Staphylococcus spp. and Streptococcus spp. – Treating infections in companion animals, such as dogs and cats. For example, it can be used to treat skin infections and certain respiratory infections in these animals. |
| Considerations | – Overuse can contribute to the development of antibiotic – resistant bacteria. Adhering to proper dosage and treatment duration as prescribed by veterinarians is crucial. – High doses or long – term use may cause gastrointestinal upset in animals, including diarrhea, vomiting, and loss of appetite. It may also disrupt the normal gut microbiota. – Caution is needed when using it in combination with other drugs. There may be potential drug – drug interactions, especially with other antibiotics that target protein synthesis, as they may compete for binding sites on the ribosome. |
Erythromycin Base plays a vital role in maintaining the health and productivity of livestock, poultry, and companion animals by effectively treating bacterial infections.
