Active Pharmaceutical Ingredients

Catalog ID 80017166

CAS NO.82159-09-9

Purity 95%

MDL NumberMFCD00865484

Molecular Formula C15H13NO3S2

Molecular Weight 319.404

Melting point: 210~217°C

Aspect	Details
Chemical Properties	– Molecular Formula: C15H13NO3S2<br>- Molecular Weight: 323.35 g/mol<br>- CAS Number: 82159-09-9<br>- Physical Appearance: White to off-white crystalline powder
Mechanism of Action	Epalrestat is a non-competitive, reversible inhibitor of aldose reductase, a rate-limiting enzyme in the polyol pathway. It reduces intracellular sorbitol accumulation, which is implicated in the pathogenesis of diabetic complications such as neuropathy, retinopathy, and nephropathy.
Indications	– Treatment of diabetic neuropathy.<br>- Potential use in non-alcoholic steatohepatitis (NASH) by inhibiting NLRP3 inflammasome activation.
Pharmacokinetics	– Absorption: Rapidly absorbed after oral administration.<br>- Distribution: Widely distributed in tissues.<br>- Metabolism: Metabolized in the liver.<br>- Excretion: Primarily excreted in urine.
Adverse Effects	– Common: Nausea, headache, dizziness.<br>- Rare: Allergic reactions.
Contraindications	Hypersensitivity to epalrestat or any of its components.
Special Considerations	– Use with caution in patients with liver or kidney impairment.<br>- Monitor for signs of gastrointestinal disturbances.
Storage Conditions	Store in a cool, dry place, protected from light and moisture

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