Epalrestat CAS NO.82159-09-9
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID 80017166
CAS NO.82159-09-9
Purity 95%
MDL NumberMFCD00865484
Molecular Formula C15H13NO3S2
Molecular Weight 319.404
Melting point: 210~217°C
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C15H13NO3S2<br>- Molecular Weight: 323.35 g/mol<br>- CAS Number: 82159-09-9<br>- Physical Appearance: White to off-white crystalline powder |
| Mechanism of Action | Epalrestat is a non-competitive, reversible inhibitor of aldose reductase, a rate-limiting enzyme in the polyol pathway. It reduces intracellular sorbitol accumulation, which is implicated in the pathogenesis of diabetic complications such as neuropathy, retinopathy, and nephropathy. |
| Indications | – Treatment of diabetic neuropathy.<br>- Potential use in non-alcoholic steatohepatitis (NASH) by inhibiting NLRP3 inflammasome activation. |
| Pharmacokinetics | – Absorption: Rapidly absorbed after oral administration.<br>- Distribution: Widely distributed in tissues.<br>- Metabolism: Metabolized in the liver.<br>- Excretion: Primarily excreted in urine. |
| Adverse Effects | – Common: Nausea, headache, dizziness.<br>- Rare: Allergic reactions. |
| Contraindications | Hypersensitivity to epalrestat or any of its components. |
| Special Considerations | – Use with caution in patients with liver or kidney impairment.<br>- Monitor for signs of gastrointestinal disturbances. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture |
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