Entrectinib
We are a manufacturer based in China. We specialize in providing high-quality Entrectinib for industrial clients across various sectors. Whether you need chemicals consultation or technical support, our team is here to help.
Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms RXDX101 NMS-E628 N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide
Catalog ID100841
CAS NO.1108743-60-7
Purity 95%
MDL NumberMFCD28129099
EINEC Molecular FormulaC31H34F2N6O2
Molecular Weight 560.646”
| Category | Content |
|---|---|
| Generic Name | Entrectinib |
| Brand Name | Rozlytrek |
| Drug Class | Tyrosine Kinase Inhibitor |
| Mechanism of Action | Entrectinib is a selective inhibitor of TRKA, TRKB, TRKC (encoded by NTRK1, NTRK2, NTRK3), ROS1, and ALK. It acts as an ATP competitor to block these kinases, suppressing cancer cell proliferation and promoting apoptosis. |
| Indications | – Treatment of ROS1-positive metastatic non-small cell lung cancer (NSCLC) in adults.<br>- Treatment of NTRK gene fusion-positive solid tumors in adults and children aged 1 month and older.<br>- Effective against primary and metastatic central nervous system (CNS) diseases. |
| Dosage Forms | Capsules, oral suspension, or oral pellets. |
| Administration | – Adults: 600 mg orally once daily.<br>- Children (12 years and older): 300 mg/m² orally once daily.<br>- Can be taken with or without food. |
| Pharmacokinetics | – Tmax: 4-5 hours.<br>- Half-life: 20 hours (parent drug), 40 hours (active metabolite M5).<br>- Crosses the blood-brain barrier. |
| Side Effects | – Common: Fatigue, nausea, constipation, increased liver enzymes.<br>- Serious: Severe liver toxicity, seizures. |
| Developer | Roche |
| Approval Date | Approved by the FDA in August 2019. |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.
Inquiry
Factory & Shipment
