Enalaprilat dihydrate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80071739
CAS NO.84680-54-6
Purity 98%
MDL NumberMFCD00941393
EINEC278-459-3
Molecular formula C18H24N2O5.2H2O
Molecular weight 384.426
Melting point: 151-159°C
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Aspect
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Details
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General Information
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Enalaprilat dihydrate is a key pharmaceutical compound. Its chemical formula is C₂₀H₂₈N₂O₇·2H₂O. It is the active metabolite of enalapril, which is a prodrug. Enalaprilat dihydrate exists as a white to off – white powder. It is sparingly soluble in water, but its solubility can be adjusted in pharmaceutical formulations for proper delivery.
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Pharmacological Action
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It belongs to the class of angiotensin – converting enzyme (ACE) inhibitors. By inhibiting ACE, it blocks the conversion of angiotensin I to angiotensin II. This leads to vasodilation as angiotensin II is a potent vasoconstrictor. Additionally, it reduces aldosterone secretion, which helps in decreasing sodium and water reabsorption, thus lowering blood volume and further contributing to blood pressure reduction.
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Clinical Applications
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Mainly used in the treatment of hypertension. It can be administered intravenously in cases where rapid blood pressure control is required, such as in hypertensive emergencies. It is also beneficial for patients with heart failure, as it improves cardiac function by reducing the afterload on the heart.
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Adverse Reactions
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Common side effects may include cough, which is thought to be due to the accumulation of bradykinin as a result of ACE inhibition. Hypotension can occur, especially in patients who are volume – depleted or taking other blood – pressure – lowering medications. Hyperkalemia may also be observed as the reduced aldosterone levels affect potassium excretion.
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Precautions
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Patients with renal impairment need close monitoring as enalaprilat dihydrate can affect kidney function. Pregnant women should avoid using it as it may cause harm to the fetus. It is important to inform healthcare providers about all existing medications to prevent potential drug – drug interactions.
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Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
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