Enalapril maleate CAS NO.76095-16-4
We specialize in providing high-quality Enalapril maleate CAS NO.76095-16-4 for industrial clients across various sectors. Whether you need chemicals consultation, technical support, or detailed information about our production capabilities, our team is here to help.
Category：Active Pharmaceutical Ingredients MOQ:100KG Shipped directly from China
Introduction
Catalog ID80016999
CAS NO.76095-16-4
Purity98%
MDL NumberMFCD00133304
EINEC278-375-7
Molecular FormulaC20H28N2O5.C4H4O4
Molecular Weight492.5189
| Aspect | Details |
|---|---|
| Chemical Structure | – Molecular Formula: C₂₄H₃₂N₂O₉<br>- Molecular Weight: 492.52 |
| Mechanism of Action | – Enalapril maleate is a prodrug that is hydrolyzed in the body to its active form, enalaprilat, which is a potent inhibitor of angiotensin-converting enzyme (ACE).<br>- Inhibition of ACE reduces the formation of angiotensin II, leading to decreased peripheral vascular resistance and lower blood pressure. |
| Clinical Uses | – Used in the treatment of hypertension, chronic heart failure, and diabetic nephropathy.<br>- Effective in reducing blood pressure in patients with essential and renovascular hypertension.<br>- Improves cardiac performance by reducing preload and afterload in patients with severe congestive heart failure. |
| Pharmacokinetics | – Orally administered enalapril maleate is hydrolyzed to enalaprilat, which is 60% absorbed and 40% bioavailable.<br>- Enalaprilat has a functional half-life of 11 hours, which is prolonged in patients with reduced renal function.<br>- Both enalapril and enalaprilat are primarily excreted renally without further metabolism. |
| Dosage Forms | – Tablets: 2.5 mg, 5 mg, 10 mg, 20 mg.<br>- Typically administered once or twice daily. |
| Storage Conditions | – Store at -20°C in a freezer.<br>- Protect from moisture. |
| Side Effects | – Common: Hypotension in hypovolemic patients, reduced renal function in certain patients with renovascular hypertension.<br>- Rare: Rash, angioedema.<br>- Enalapril does not cause bradycardia or adverse effects on laboratory values associated with diuretics. |
| Research Applications | – Studied for its effects on blood pressure, renal function, and cardiac performance in various animal models.<br>- Investigated for its potential in treating hypertension and heart failure. |
| Synonyms | – Vasotec Maleate<br>- Renitec Maleate<br>- MK-421 Maleate |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
If you're ready to take the next step or simply have a few questions, our experts are here to help. Connect with us today to learn more. ↓↓↓
Inquiry
Factory & Shipment
