Eflornithine HCl CAS NO.68278-23-9
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID 80017184
CAS NO.68278-23-9
Purity 97%
MDL NumberMFCD00274036
EINEC269-532-0
Molecular Formula C6H12F2N2O2.HCl
Molecular Weight 218.6294
Melting point: 259~261°C
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C6H15ClF2N2O3<br>- Molecular Weight: 209.11 g/mol<br>- CAS Number: 96020-91-6 |
| Mechanism of Action | Eflornithine is an irreversible inhibitor of the enzyme ornithine decarboxylase (ODC), which is involved in the synthesis of polyamines. By inhibiting ODC, it reduces the production of polyamines, which are essential for cell proliferation. This mechanism is particularly effective in treating conditions such as African trypanosomiasis and reducing unwanted facial hair. |
| Indications | – Treatment of second-stage African trypanosomiasis (sleeping sickness).<br>- Reduction of unwanted facial hair in women. |
| Pharmacokinetics | – Absorption: Peak plasma concentrations (Cmax) achieved 3.5 hours post-dosing.<br>- Distribution: Volume of distribution (Vz/F) is 24.3 L.<br>- Metabolism: Not significantly metabolized.<br>- Excretion: Primarily excreted unchanged in urine.<br>- Clearance: 5.3 L/h. |
| Dosage Forms | – Oral tablets.<br>- Topical cream (e.g., Vaniqa) for facial hair reduction. |
| Storage Conditions | Store at -20°C (frozen) to maintain stability. |
| Adverse Effects | – Common: Nausea, vomiting, headache, dizziness.<br>- Topical use may cause skin irritation. |
| Contraindications | Hypersensitivity to eflornithine or any of its components. |
| Special Considerations | – Use with caution in patients with liver or kidney impairment.<br>- Monitor for signs of gastrointestinal disturbances |
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