Econazole Nitrate CAS No.: 68797-31-9
Active Pharmaceutical Ingredients 2025-03-03
Molecular Formula: C18H15Cl3N2O,HNO3
Molecular Weight: 444.7
CAS No.: 68797-31-9
Econazole nitrate is a pyrrole antifungal drug and a dechlorinated derivative of miconazole. It has antibacterial activity against Candida, chromomycetes, coccidiospores, histoplasm, Sporothrix, and Trichophyton.
Description
The product is white or yellowish crystalline or crystalline powder; Odorless. The product is easily soluble in methanol, slightly soluble in chloroform and very slightly soluble in water. Melting point the melting point of the product (Appendix VI C) is 163 ~ 167 ℃, and it decomposes at the same time when melting.
Application
For the treatment of cutaneous candidiasis; It can also be used to treat tinea corporis, tinea manus, tinea cruris, tinea pedis, tinea versicolor, etc.
Packing and Storage
Preserve in well-closed containers, protected from light.
Minimum Order
One package
| Title | Content |
|---|---|
| Introduction | Econazole Nitrate is an antifungal medication used to treat various fungal skin infections. It is available in topical forms such as creams and foams. |
| Mechanism of Action | Econazole Nitrate is an imidazole derivative that inhibits the biosynthesis of ergosterol, a key component of fungal cell membranes. This disruption prevents fungal growth and kills the fungus. |
| Medical Uses | – Athlete’s Foot (Tinea Pedis)<br>- Jock Itch (Tinea Cruris)<br>- Ringworm (Tinea Corporis)<br>- Cutaneous Candidiasis<br>- Tinea Versicolor<br>- Interdigital Tinea Pedis (Foam Formulation) |
| Dosage Forms | – Topical Cream: Applied once or twice daily depending on the condition.<br>- Topical Foam: Applied once daily for conditions like interdigital tinea pedis. |
| Common Side Effects | – Skin Reactions: Burning, itching, stinging, redness, and dryness at the application site.<br>- Allergic Reactions: Skin rash, swelling, or irritation. |
| Serious Side Effects | – Long-term Use: Potential for skin atrophy, telangiectasia, and secondary infections.<br>- Systemic Effects: Rare but may include headache or nausea. |
| Precautions | – Avoid contact with eyes, nose, mouth, and vagina.<br>- Do not use on viral infections like herpes or chickenpox.<br>- Use only as directed by your doctor to avoid irritation or resistance. |
| Storage Conditions | Store at room temperature (20°C to 25°C). Do not refrigerate or freeze the foam formulation. |
