Dropropizine CAS NO.17692-31-8
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017877
CAS NO.17692-31-8
Purity 98%
MDL NumberMFCD00079124
Molecular Formula C13H20N2O2
Molecular Weight 236.3101
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C13H20N2O2<br> Molecular weight: 236.31 g/mol |
| Mechanism of Action | Peripheral antitussive agent that inhibits the cough reflex by acting on peripheral receptors and their afferent conductors. |
| Therapeutic Uses | Cough Suppression: Effective for treating cough in both adults and children. It has been shown to be more effective than central antitussives like codeine and dextromethorphan.<br> Clinical Guidelines: Recommended by the American College of Chest Physicians (ACCP) for short-term symptomatic relief of cough due to acute or chronic bronchitis. |
| Pharmacokinetics | Absorption: Rapidly absorbed with peak plasma concentrations reached within 1–2 hours.<br> Distribution: Widely distributed in tissues.<br> Metabolism: Metabolized in the liver.<br> Excretion: Primarily excreted in urine. |
| Safety and Side Effects | Generally well-tolerated with minimal side effects. Central antitussives like codeine and dextromethorphan can cause drowsiness, dependency, and other adverse effects, whereas dropropizine does not have these issues. |
| Storage Conditions | Store powder at -20°C for 3 years; in solvent at -80°C for 1 year. |
| Synonyms | Hydroxypropylpiperazine, UCB-1967, (±)-Dropropizine |
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