Active Pharmaceutical Ingredients

CAS NO：10592-13-9

Name	Doxycycline HCl
Synonyms	DOXYCYCLINE HCL VIBRAMYCIN, HCL Doxycycline HCl DOXYCYCLINE HYDROCHLORIDE Doxycycline Hydrochloride DOXYCYCLINI HYDROCHLORIDUM ALPHA-6-DEOXY-5-HYDROXYTETRACYCLINE Doxycycline Hydrochloride Anhydrous 4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 2-(AMINO-HYDROXY-METHYLIDENE)-4-DIMETHYLAMINO-5,10,11,12A-TETRAHYDROXY-6-METHYL-4A,5,5A,6-TETRAHYDRO-4H-TETRACENE-1,3,12-TRIONE (4s,4ar,5s,5ar,6r,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride (2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride (1S,3Z,4aS,11R,11aR,12S,12aR)-3-[amino(hydroxy)methylidene]-4a,6,7,12-tetrahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chloride
CAS	10592-13-9 100929-47-3
EINECS	234-198-7
InChI	InChI=1/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H/t7-,10+,14+,15-,17-,22-;/m0./s1

10592-13-9 – Physico-chemical Properties

Molecular Formula	C22H25ClN2O8
Molar Mass	480.9
Melting Point	206-209°C
Boling Point	685.2°C at 760 mmHg
Specific Rotation(α)	D25 -110° (c = 1 in 0.01N methanolic HCl)
Solubility	water: 50 mg/mL
Appearance	crystalline solid(yellow to yellow-green)
Storage Condition	2-8℃
MDL	MFCD07357237
Use	Antibiotics for infections caused by gram-positive cocci and gram-negative bacilli

10592-13-9 – Upstream Downstream Industry

Raw Materials

Quinaldine N-Acetylaniline Starch potato Dextrose Anhydrate Oxytetracycline Ethyl Alcohol

10592-13-9 – Reference

Reference

1. Liang Jinling, Huang Yuxia, He Jinxing. Determination of Tetracycline Antibiotic Residues in Chicken by Molecularly Imprinted Solid Phase Extraction-High Performance Liquid Chromatography [J]. 2018 of Modern Food Science and Technology v.34;No.227(07):224-229. 2. Zhang Jipei, Wei Qinglan, Tan Hualong, et al. Drug resistance and drug resistance gene detection of waterfowl Escherichia coli to tetracycline in Guangdong [J]. Animal Husbandry and Veterinary Medicine, 2015, 47(012):94-97. 3. Ma Zhenzhen, Zhao Tao, he Jinxing. Preparation of Tetracycline Molecularly Imprinted-Biochar Composites by Pickering Emulsion Polymerization [C]// Abstracts of the 15th Annual Meeting of China Food Science and Technology Society. 2018. 4. Cen Daoji, Mai Jialin, Zhou Yuyuan, et al. Drug Resistance Status of Escherichia coli in Guangdong Goose Farm and Transmission Characteristics of blaCTX-M Genes [J]. China Animal Husbandry and Veterinary Medicine, 202,047 (005):1571-1582.

10592-13-9 – Standard

This product is 6-methyl -4-(dimethylamino)-3,5,10,12, 12a-pentahydroxy-1, 11-dioxo-1, 4,4a,5,5a,6,11, 12a-octahydro -2-tetrabenzamide hydrochloride hemiethanol hemihydrate. Doxycycline-containing (C22H24N208) should be between 88.0% and 94.0% based on anhydrous and ethanol-free material.

10592-13-9 – Trait

• This product is light yellow to yellow crystalline powder; Odorless.
• This product is soluble in water or methanol, and slightly soluble in ethanol or acetone.

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specific rotation

take this product, precision weighing, add hydrochloric acid solution (9-100) of methanol solution (1-100) dissolved and quantitatively diluted to make a solution containing about 10 mg per 1 ml, at 25°C, determination according to law (General rule 0621), calculated as anhydrous and alcohol-free, the specific rotation is 105 ° to -120 °.

 

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