Active Pharmaceutical Ingredients

Catalog ID80017114

CAS NO.10592-13-9

Purity 98%

MDL NumberMFCD03427564

EINEC234-198-7

Molecular FormulaC22H24N2O8.HCl

Molecular Weight480.8955

Melting point: 195~201°C

Aspect	Details
Chemical Structure	Memantine HCl has the chemical formula C₁₂H₂₁N·HCl. Its chemical name is 1-amino-3,5-dimethyladamantane hydrochloride.
Mechanism of Action	Memantine is a low-to-moderate-affinity, voltage- and use-dependent NMDA receptor antagonist. It modulates the activity of glutamate, a neurotransmitter involved in learning and memory, by binding to the NMDA receptor and preventing excessive calcium influx, which is associated with neuronal damage in Alzheimer’s disease.
Clinical Uses	It is used for the treatment of moderate to severe Alzheimer’s disease to improve cognitive function and delay disease progression.
Formulations	Available as immediate-release tablets/capsules (5 mg, 10 mg) and extended-release capsules (7 mg, 28 mg). The extended-release formulation allows for once-daily dosing.
Pharmacokinetics	– Absorption: Well-absorbed orally, with peak plasma concentrations reached in 3–7 hours.<br>- Distribution: Mean volume of distribution is 9–11 L/kg.<br>- Metabolism: Primarily excreted unchanged in urine (48–82%). Metabolized to three main metabolites with minimal NMDA receptor activity.<br>- Elimination: Terminal half-life is approximately 60–80 hours.
Special Precautions	– Use with caution in patients with renal impairment. Dose adjustment is required for severe renal impairment (creatinine clearance 5–29 mL/min).<br>- Monitor patients for potential adverse effects such as dizziness, headache, and constipation.<br>- Avoid concurrent use with other central nervous system depressants.<br>- Not recommended for patients with a history of epilepsy or seizure disorders.<br>- Pregnant and breastfeeding women should use with caution.
Side Effects	Common side effects include dizziness, headache, constipation, and hypertension. Serious side effects may include hallucinations, confusion, anxiety, and renal dysfunction.
Storage Conditions	Store at room temperature (15–30°C) in a dry place

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