Doxepin HCl CAS NO.1229-29-4
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017811
CAS NO.1229-29-4
Purity 99%
MDL NumberMFCD00079135
EINEC214-966-8
Molecular FormulaC19H21NO.HCl
Molecular Weight315.8371
Melting point: 185 ~191 °C
| Aspect | Details |
|---|---|
| Mechanism of Action | Doxepin HCl is a tricyclic antidepressant that increases the concentration of serotonin (5-HT) and norepinephrine (NE) in the brain by inhibiting their reuptake into the presynaptic terminal. It also acts as an antagonist at histamine (H1), α1 adrenergic, and muscarinic receptors, which contributes to its sedative and antipruritic effects. |
| Resistance and Combination Therapy | Resistance to doxepin can occur due to genetic variations in drug metabolism (e.g., CYP2D6 polymorphisms) or due to long-term use leading to receptor desensitization. Combination therapy with other agents, such as benzodiazepines for insomnia or NSAIDs for pain management, may be used to enhance efficacy. |
| Storage Conditions | Doxepin HCl capsules and oral concentrate should be protected from direct sunlight and stored in well-closed, light-resistant containers at a temperature between 15°C and 30°C |
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