Doxapram HCl CAS NO.7081-53-0
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID 80017757
CAS NO.7081-53-0
Purity 98%
MDL NumberMFCD00072148
Molecular Formula C24H30N2O2.HCl
Molecular Weight 414.9681
Melting point: 217~219°C
| Aspect | Details |
|---|---|
| Mechanism of Action | Doxapram HCl is a respiratory stimulant that acts through peripheral carotid chemoreceptors and directly stimulates the central respiratory center. It increases the medullary respiratory drive, resulting in increased tidal volume and respiratory rate. |
| Indications | – Used to stimulate respiration in patients with respiratory depression due to anesthesia or other causes.<br>- May also be used to treat apnea of prematurity and other conditions where respiratory support is needed. |
| Pharmacokinetics | – Distribution: Volume of distribution is 1.51 L/kg.<br>- Metabolism: Metabolized to several active metabolites.<br>- Elimination: Plasma concentration declines in a multi-exponential fashion with a half-life of approximately 3.4 hours.<br>- Excretion: Less than 5% of an IV dose is excreted unchanged in urine within 24 hours. |
| Side Effects | – Common: Pain and redness at the injection site, warmth, flushing, sweating, headache, dizziness, nausea, diarrhea, and enlarged pupils.<br>- Serious: Cardiac arrhythmias (e.g., ventricular tachycardia, fibrillation), hypertension, seizures, and QT interval prolongation.<br>- Neonates: QT interval prolongation, bloody stools, necrotizing enterocolitis, neurodevelopmental delay, and other adverse effects. |
| Precautions | – Use with caution in patients with hypertension, cardiovascular disease, or chronic obstructive pulmonary disease (COPD).<br>- Avoid rapid infusion to prevent hemolysis and other adverse effects.<br>- Monitor blood pressure, pulse rate, and deep tendon reflexes to prevent overdose.<br>- Not recommended for patients with epilepsy or other seizure disorders.<br>- Caution in patients receiving sympathomimetic or monoamine oxidase inhibiting drugs. |
| Contraindications | – Hypersensitivity to doxapram or any component of the injection.<br>- Patients with epilepsy or other seizure disorders. |
| Storage Conditions | This medication is typically administered in a hospital or clinic setting and is not stored at home |
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