Dofetilide
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID 80071717
CAS NO.115256-11-6
Purity 98+%
MDL NumberMFCD00869707
Molecular Formula C19H27N3O5S2
Molecular Weight 441.5648
Melting point: 157~159°C
| Item | Information |
|---|---|
| Mechanism of Action | Dofetilide is a Class III antiarrhythmic agent that blocks the rapid component of the delayed rectifier potassium current (IKr), prolonging the QT interval and increasing the refractory period of cardiac cells. It also inhibits the late sodium current (INaL), which may contribute to its arrhythmogenic potential. |
| Indications | – Maintenance of normal sinus rhythm (delaying recurrence of atrial fibrillation/atrial flutter) in patients with symptomatic atrial fibrillation/atrial flutter lasting longer than one week.<br>- Conversion of atrial fibrillation/atrial flutter to normal sinus rhythm. |
| Special Precautions | – Contraindicated in patients with long QT syndrome, severe renal impairment (creatinine clearance <20 mL/min), or baseline QTc >440 msec.<br>- Avoid concurrent use with drugs that inhibit renal cation transport (e.g., cimetidine, trimethoprim, ketoconazole) or CYP3A4 inhibitors.<br>- Monitor electrolyte levels (potassium, magnesium) and QT interval during therapy.<br>- Use with caution in patients with hepatic impairment.<br>- Not recommended for use in patients with paroxysmal atrial fibrillation. |
| Dosing Considerations | – Adjust dose based on creatinine clearance.<br>- Avoid doubling the dose if a dose is missed. |
| Monitoring Requirements | Regular monitoring of renal function, QT interval, and electrolyte levels is necessary to minimize the risk of serious arrhythmias. |
| Patient Education | Patients should be informed about the potential for drug interactions, the importance of compliance, and the need to report any changes in medication use. |
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