DL-Naproxen
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID816109
CAS NO.22204-53-1
Purity 97%
MDL NumberMFCD00010500
EINEC244-838-7
Molecular formula C14H14O3
Molecular weight 230.2592
Melting point: 156~158°C
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Aspect
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Details
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Pharmacological Mechanism
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DL – Naproxen is a non – steroidal anti – inflammatory drug (NSAID). It works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX – 1 and COX – 2. By blocking these enzymes, it reduces the synthesis of prostaglandins. Prostaglandins are involved in the body’s inflammatory response, pain perception, and fever regulation. The inhibition of prostaglandin synthesis leads to a decrease in inflammation, pain, and fever.
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Clinical Applications
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In clinical practice, DL – Naproxen is widely used for the relief of pain associated with various conditions. It is effective in treating mild to moderate pain, such as headaches, menstrual cramps, and musculoskeletal pain. It is also prescribed for the management of inflammatory conditions like rheumatoid arthritis and osteoarthritis, where it helps to reduce joint pain, swelling, and stiffness, improving the patient’s quality of life and joint function.
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Adverse Reactions
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However, like other NSAIDs, DL – Naproxen may cause several adverse reactions. Gastrointestinal side effects are common, including nausea, vomiting, indigestion, and in severe cases, peptic ulcers and gastrointestinal bleeding. It can also affect the kidneys, potentially leading to renal impairment, especially in patients with pre – existing kidney problems or those on long – term use. Cardiovascular risks such as an increased risk of heart attack and stroke have also been associated with the use of NSAIDs, including DL – Naproxen, especially at higher doses.
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Precautions
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Patients with a history of peptic ulcers, heart disease, or kidney disease should use DL – Naproxen with caution. It is important to avoid alcohol while taking this drug as it can increase the risk of gastrointestinal bleeding. Pregnant and breastfeeding women should consult their healthcare providers before using DL – Naproxen, as it may have potential effects on the fetus or nursing infant. Additionally, patients should inform their doctors about all the medications they are taking to avoid possible drug interactions.
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Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
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