Dimyristoyl-rac-glycerol-PEG
Other Pharmaceutical 2025-03-04
CAS: 1397695-86-1
Catalog: HY-141674
| Aspect | Details |
|---|---|
| Structure | DMG-PEG 2000, also known as 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, consists of a glycerol backbone, two saturated C14:0 fatty acid chains, and a PEG 2000 chain. |
| Molecular Weight | Approximately 2509.2 Da. |
| Solubility | Soluble in ethanol, chloroform, and DMSO at concentrations up to 10 mg/mL. |
| Storage | Store at -20°C. |
| Applications | Widely used in the preparation of lipid nanoparticles (LNPs) and liposomes for RNA delivery, including mRNA, siRNA, and plasmid DNA. It is a key component in the development of COVID-19 mRNA vaccines. |
| Advantages | Solves the “PEG-dilemma” by allowing easier endosomal escape and reducing immunogenicity. The short C14 fatty acid chains enable rapid dissociation from the lipid membrane, enhancing drug delivery efficiency. |
| Research Use | For research purposes only, not for human use |
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