Dimesna (Disodium 2,2′-dithiobisethane sulfonate)
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80020384
CAS NO.16208-51-8
Purity 95+%
MDL NumberMFCD00868218
Molecular Formula C4H8Na2O6S4
Molecular Weight 326.3423
Melting point: 305~307°C
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₄H₈Na₂O₆S₄<br>- Molecular Weight: 326.34 g/mol |
| Physical Properties | – Appearance: White to off-white powder<br>- Melting Point: 273°C (decomposition) |
| Mechanism of Action | – Dimesna reacts with toxic metabolites such as acrolein to form stable, non-toxic compounds.<br>- It protects the bladder wall from the harmful effects of certain cancer-fighting drugs. |
| Biological Activities | – Reduces nephrotoxicity when combined with anticancer chemotherapeutic agents.<br>- Prevents or mitigates cisplatin-induced nephrotoxicity. |
| Clinical Uses | – Used to protect against the urotoxic effects of oxazaphosphorines (e.g., cyclophosphamide, ifosfamide).<br>- Investigated in clinical trials for reducing toxicity in cancer treatment. |
| Storage Conditions | – Store at 4°C, sealed, away from moisture.<br>- In solvent: -80°C for 6 months; -20°C for 1 month. |
| Solubility | – Soluble in water (100 mg/mL) with sonication.<br>- Soluble in DMSO (68 mg/mL) with heating. |
| Synonyms | – Disodium 2,2′-dithiodiethanesulfonate<br>- Tavocept<br>- BNP7787 |
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