Active Pharmaceutical Ingredients

Catalog ID80021362

CAS NO.27200-12-0

Purity 98%

MDL NumberMFCD00189451

Molecular Formula C15H12O8

Molecular Weight 320.25

Melting point: 240~256°C

Category	Information
Biological Activities	Dihydromyricetin (DHM) is a flavonoid with multiple biological benefits. It exhibits anti-inflammatory, antioxidant, anti-tumor, and anti-viral activities. It is also a potent dihydropyrimidinase inhibitor with an IC50 of 48 μM. Additionally, DHM can activate autophagy by inhibiting the mTOR signaling pathway.
Mechanisms of Action	DHM inhibits the formation of mTOR complexes (mTORC1/2), which helps in regulating cell growth and survival. It also acts as an inhibitor of the influenza virus RNA-dependent RNA polymerase, with an IC50 of 22 μM.
Pharmacological Applications	DHM has been studied for its effects on various systems, including cardiovascular, urinary, digestive, nervous, and respiratory systems. It is recognized for its high biosafety, making it a promising candidate for clinical applications.
Research Findings	Recent studies have shown that DHM can attenuate brain aging in rats induced by D-galactose through the miR-34a-mediated SIRT1/mTOR signal pathway. It also suppresses breast carcinogenesis by inhibiting the mTOR signaling pathway.
Storage and Stability	DHM should be stored at -20°C as a powder for up to 2 years. When dissolved in a solvent, it should be stored at -80°C for up to 1 year.

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