Pharmaceutical Materials

Diethyl malonate (DEM) is a pivotal β-dicarbonyl compound widely utilized in organic synthesis, pharmaceuticals, agrochemicals, and flavorings. Its utility stems from its ability to undergo diverse reactions, including hydrolysis, decarboxylation, acylation, alkylation, and Michael addition, making it a versatile intermediate. DEM serves as a precursor for barbiturates, sulfonamides, and anti-malarial drugs like chloroquine. It is also essential in producing herbicides (e.g., bensulfuron-methyl) and dyes (e.g., benzimidazolone pigments). As a food additive (FEMA No. 2375), it imparts fruity notes to flavors. Industrial synthesis primarily relies on cyanide-based esterification, though alternative methods like catalytic carbonylation are explored. Safety protocols emphasize storage away from oxidizers and heat, with protective measures for handling its corrosive hydrolysis products.

Usage： Diethyl malonate is an important fine chemical raw material and organic synthesis intermediate, widely used in a variety of chemical production fields, including food, medicine, pesticide, industrial dyes, liquid crystal materials and other industries.

Packaging and Shipping： 200KG/drum or as per buyer requirements.

Storage: Store in a ventilated, cool, dry warehouse; Keep the container closed, away from heat source and open fire, and Separate store with strong oxidant, food additives.

Name	Diethyl malonate
CAS No.	105-53-3
Molecular Formula	C₇H₁₂O₄
Molecular Weight	160.17 g/mol
Appearance	Colorless liquid with sweet, ethereal odor
Melting Point	-50°C
Boiling Point	199°C
Flash Point	93.3°C
Synthesis	Esterification of malonic acid with ethanol under acidic conditions
Applications	Organic synthesis intermediate (barbiturates, ethoxy methylene), pharmaceuticals (sulfonamides), food flavoring, GC fixed liquid
Safety	Irritant to eyes, skin, mucous membranes; flammable. Store in cool, ventilated area away from heat/oxidizers. Use PPE (goggles, gloves).
Packaging	200kg drums (iron or galvanized)

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