Diclofenac sodium CAS NO.15307-79-6
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017813
CAS NO.15307-79-6
Purity 98%
MDL NumberMFCD00082251
EINEC239-346-4
Molecular FormulaC14H10Cl2NNaO2
Molecular Weight 318.1305
Melting point: 279~289℃
| Aspect | Details |
|---|---|
| Mechanism of Action | Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, thereby reducing the synthesis of pro-inflammatory prostaglandins. It also down-regulates sensitized peripheral pain receptors by stimulating the L-arginine/nitric oxide (NO)/cGMP pathway. |
| Pharmacokinetics | Diclofenac sodium is rapidly absorbed when administered orally and reaches peak plasma concentrations within 1 to 2 hours. It is highly protein-bound (99%) and has a half-life of approximately 1 to 2 hours. The drug is metabolized in the liver and excreted mainly in the urine. |
| Administration | Available in various forms, including oral tablets, suspension, intramuscular injection, intravenous injection, transdermal gel, and rectal suppositories. For acute pain, intravenous bolus injections can be administered. |
| Adverse Effects | Common side effects include gastrointestinal upset, nausea, vomiting, and abdominal pain. Prolonged use may lead to gastrointestinal ulcers, bleeding, and renal impairment. |
| Storage Conditions | Diclofenac sodium should be stored at room temperature (15° to 30°C) and protected from light. |
| Special Considerations | Use with caution in patients with a history of gastrointestinal ulcers, renal impairment, or cardiovascular disease. Concurrent use with other NSAIDs or anticoagulants may increase the risk of adverse effects |
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