Dichlorotrifluoromethylpyridine
Pharmaceutical Materials 2025-03-02
The usage and synthesis of dichlorotrifluoromethylpyridine. It is prepared by using 2-amino-5-methylpyridine as raw material, firstly chlorinated, then diazotized, and reacted in the presence of CuCl to obtain 2,3-dichloro-5-trichloromethylpyridine, and then reacted with hydrogen fluoride to obtain the product. It is also possible to use 2-chloro-5-methylpyridine as raw material, first chlorinate the side chain to obtain 2-chloro-5-trichloromethylpyridine, then further chlorinate on the ring to obtain 2,3-dichloro-5-trichloromethylpyridine, and then fluorinate with hydrogen fluoride to obtain the product. The preparation method is to use 3-methylpyridine as raw material in the presence of a catalyst, chlorination and fluorination to produce this product. It is also possible to use 2-chloro-5-trichloromethylpyridine for cyclic chlorination to obtain 2,3-dichloro-5-trichloromethylpyridine, and then fluorinated with hydrogen fluoride to obtain the product.
| Chemical Formula | C₆H₂Cl₂F₃N |
| Molecular Weight | 215.99 g/mol |
| Appearance | Colorless to yellow liquid |
| Density | 1.5±0.1 g/cm³ or 2.008 g/mL at 25 °C |
| Melting Point | 194 °C |
| Boiling Point | 194-196 °C at 760 mmHg or 221.0±35.0 °C at 760 mmHg |
| Flash Point | 87.5±25.9 °C or 218 °F |
| Refractive Index | 1.470 or 1.4855 |
| Vapor Pressure | 0.2±0.4 mmHg at 25°C |
| Solubility | Insoluble in water, soluble in chloroform, ethanol, ether, and acetone |
| Applications | Intermediate in the production of dyes, pesticides, and pharmaceuticals |
| Safety Information | Corrosive; wear protective gloves, goggles, and clothing; avoid inhaling vapors, aerosols, or gases; classified as flammable liquid (Category 4), skin corrosive (Category 1B), and causing serious eye damage (Category 1) under GHS |
| Regulatory Status | CAS No.: 55304-75-1; EINECS No.: 259-585-8; Hazardous goods transport code: UN 3265 8/PG 2; WGK Germany: 3; Customs code: 2933599090 |
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