Pharmaceutical Materials

The use and synthesis of dichlorotrifluoromethylpyridine. It is prepared by using 2-amino-5-methylpyridine as raw material, firstly chlorinated, then diazotized, and reacted in the presence of CuCl to obtain 2,3-dichloro-5-trichloromethylpyridine, and then reacted with hydrogen fluoride to obtain the product. It is also possible to use 2-chloro-5-methylpyridine as raw material, first chlorinate the side chain to obtain 2-chloro-5-trichloromethylpyridine, then further chlorinate on the ring to obtain 2,3-dichloro-5-trichloromethylpyridine, and then fluorinate with hydrogen fluoride to obtain the product. The preparation method is to use 3-methylpyridine as raw material in the presence of a catalyst, chlorination and fluorination to produce this product. It is also possible to use 2-chloro-5-trichloromethylpyridine for cyclic chlorination to obtain 2,3-dichloro-5-trichloromethylpyridine, and then fluorinated with hydrogen fluoride to obtain the product.,Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.