Active Pharmaceutical Ingredients

Catalog ID80019499

CAS NO.2438-32-6

Purity 98%

MDL NumberMFCD00079046

EINEC219-450-6

Molecular FormulaC16H19ClN2.C4H4O4

Molecular Weight390.865

Melting point: 113~117°C

Category	Details
Chemical Properties	White or almost white, crystalline powder. It is a white, odorless crystalline powder with a pH of 4.0–5.0 in aqueous solution.
Solubility	Very soluble in water, freely soluble in ethanol (96%), methanol, and methylene chloride.
Mechanism of Action	Dexchlorpheniramine maleate is a first-generation histamine H1 antagonist. It competes with histamine for H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract, thereby preventing histamine-induced symptoms such as sneezing, watery eyes, and runny nose.
Pharmacokinetics	Orally administered dexchlorpheniramine has an oral bioavailability of 40.5% in rats. It is primarily metabolized in the liver by CYP2D6, with minor contributions from CYP3A4, CYP2C11, and CYP2B1. It is excreted renally.
Storage Conditions	Store at 2–8°C.
Safety and Handling	Classified as toxic if swallowed. It may cause allergic skin reactions and serious eye damage. Wear protective clothing, gloves, and eye/face protection when handling

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