Pharmaceutical Materials

Dexamethasone palmitate (DXP), a prodrug of dexamethasone (CAS No.: 14899-36-6), functions as a glucocorticoid receptor agonist with reduced affinity (47-fold lower) compared to dexamethasone itself. This lipophilic derivative enhances drug solubility and bioavailability, facilitating sustained release and targeted delivery. DXP exhibits anti-inflammatory activity by modulating immune responses and suppressing cytokine production, making it valuable in treating inflammatory and autoimmune disorders. Research highlights its potential in rheumatoid arthritis and ocular conditions like macular edema, where sustained corticosteroid delivery is critical. DXP’s lower receptor affinity may reduce systemic side effects while maintaining therapeutic efficacy, positioning it as a promising candidate for long-term therapies requiring controlled glucocorticoid exposure.

Dexamethasone palmitate Usage: Organic synthesis intermediates and pharmaceutical intermediates. Dexamethasone palmitate Packaging and Shipping： 25KG/drum or as per buyera’s requirements Dexamethasone palmitate Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.

 

Name	Dexamethasone palmitate
Synonyms	Lipotalon Limethason Limethasone DXM-21-palmitate DEXAMETHASOME PALMITATE Dexamethasone palmitate Dexamethasone-21-palmitate 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-palmitate 21-(Palmitoyloxy)-9α-fluoro-11β,17α-dihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-palmitate Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-palmitate (6CI, 8CI) (11β,16α)-9-Fluoro-11,17-dihydroxy-16-Methyl-21-[(1-oxohexadecyl)oxy]pregna-1,4-diene-3,20-dione Palmitic acid, 21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (11beta,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl hexadecanoate Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxohexadecyl)oxy]-, (11β,16α)- Palmitic acid, 21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (8CI)
CAS	14899-36-6 80950-33-0
InChI	InChI=1/C38H59FO6/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-34(43)45-26-33(42)38(44)27(2)23-31-30-20-19-28-24-29(40)21-22-35(28,3)37(30,39)32(41)25-36(31,38)4/h21-22,24,27,30-32,41,44H,5-20,23,25-26H2,1-4H3/t27-,30+,31+,32+,35+,36+,37+,38+/m1/s1

Molecular Formula	C38H59FO6
Molar Mass	630.87
Density	1.12
Melting Point	60-65 °C
Boling Point	710.1±60.0 °C(Predicted)
Flash Point	383.2°C
Solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Vapor Presure	2.69E-23mmHg at 25°C
Appearance	Solid
Color	White to Pale Yellow
pKa	11.99±0.70(Predicted)
Storage Condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Refractive Index	1.537

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