Decitabine CAS NO.: 2353-33-5
Active Pharmaceutical Ingredients 2025-03-03
CAS NO.: 2353-33-5
Molecular formula: C8H12N4O4
Molecular weight: 228.20
Standard: enterprise standard
Content: ≥99% Packaging: 5kg/TIN
Decitabine: A Brief Introduction
Decitabine, also called 5-aza-2′-deoxycytidine, is a significant nucleoside analog in oncology. It works by inhibiting DNA methyltransferases, which is crucial for modifying the epigenetic state of cells.
Mechanism of Action
| Action | Details |
| Incorporation into DNA | Phosphorylated intracellularly to an active form, then incorporated into DNA during replication. |
| Inhibition of DNMTs | Forms a covalent complex with DNA methyltransferases, inactivating them and leading to DNA demethylation. |
| Gene Reactivation | Demethylation reactivates genes silenced by hypermethylation, regulating cell functions often disrupted in cancer. |
Clinical Applications
It’s mainly used for hematological malignancies like Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML). In MDS, it can improve patient conditions. In AML, especially for patients not suitable for intensive chemo, it may induce remission. Research on its use in solid tumors is ongoing.
Adverse Effects
Commonly, it causes myelosuppression (neutropenia, thrombocytopenia, anemia), gastrointestinal problems (nausea, vomiting, diarrhea), and may lead to liver function abnormalities and infusion – related reactions. Overall, decitabine plays an important role in treating specific cancers, though careful monitoring is needed due to its side effects.
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