Daptomycin
We are a manufacturer based in China. We specialize in providing high-quality Daptomycin for industrial clients across various sectors. Whether you need chemicals consultation or technical support, our team is here to help.
Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS NO.:103060-53-3
Molecular formula:C72H101N17O26
Molecular weight:1620.67
Standard:enterprise standard
Content：≥95.0%;98.0%
Packaging:1KG/BAG
Use to：Cyclic lipopeptide antibiotics
Daptomycin: A Cyclic Lipopeptide Antibiotic
Daptomycin is a novel antibiotic used for treating Gram – positive bacterial infections.
1. Basic Characteristics
| Aspect | Details |
|---|---|
| Classification | Cyclic lipopeptide antibiotic |
| Target | Bacterial cytoplasmic membrane |
| Spectrum | Effective against Gram – positive bacteria, including MRSA, VRE, Streptococcus pneumoniae, and Clostridioides difficile |
| Formulation | Powder for intravenous injection |
2. Mechanism of Action
| Process | Explanation |
|---|---|
| Membrane Interaction | Binds to bacterial membranes in a calcium – dependent manner, forming pores that disrupt membrane integrity |
| Ion Leakage | Causes potassium ion efflux, leading to depolarization of the membrane potential |
| Cell Death | Disrupts essential cellular processes like DNA, RNA, and protein synthesis, resulting in rapid bacterial death |
3. Clinical Use and Safety Profile
| Category | Details |
|---|---|
| Indications | – Complicated skin/soft tissue infections – Bacteremia and infective endocarditis – Right – sided endocarditis caused by Staphylococcus aureus |
| Adverse Reactions | – Musculoskeletal: Muscle pain (1 – 3%), rare rhabdomyolysis – Gastrointestinal: Nausea, diarrhea – Laboratory Abnormalities: Elevated liver enzymes, eosinophilia – Contraindications: Avoid concurrent use with statins (increased rhabdomyolysis risk) |
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