Dapagliflozin propanediol hydrate
Active Pharmaceutical Ingredients 2025-03-03
English Synonyms Dapagliflozin ((2S)-1,2-propanediol, hydrate) Dapagliflozin propanediol monohydrate
Catalog ID100644
CAS NO.960404-48-2
Purity 99%
MDL NumberMFCD28167768
EINEC Molecular FormulaC21H25ClO6.C3H8O2.H2O
Molecular Weight502.984”
| Category | Content |
|---|---|
| Generic Name | Dapagliflozin Propanediol Hydrate |
| Chemical Formula | C24H35ClO9 |
| Mechanism of Action | Dapagliflozin Propanediol Hydrate is a selective, orally active SGLT2 inhibitor that promotes glucose excretion in urine, thereby lowering blood glucose levels. |
| Indications | – Type 2 diabetes mellitus: Improves glycemic control.<br>- Heart failure: Reduces the risk of cardiovascular death and hospitalization.<br>- Chronic kidney disease: Slows kidney function decline. |
| Dosage Forms | Tablets |
| Pharmacokinetics | – High selectivity for SGLT2 over SGLT1.<br>- Good oral bioavailability. |
| Side Effects | – Common: Urinary tract infections, genital infections.<br>- Serious: Renal impairment, dehydration. |
| Storage | Store at 4°C, sealed and protected from moisture. |
| Developer | Bristol-Myers Squibb and AstraZeneca |
| Approval Date | FDA approval in January 2014 |
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