Dapagliflozin base CAS: 461432-26-8

Dapagliflozin is a white crystalline solid that is soluble in water and some organic solvents. It has a strong odor of rotten eggs. Dapagliflozin is unstable under high temperature and bright light...

Introduction

Dapagliflozin is a white crystalline solid that is soluble in water and some organic solvents. It has a strong odor of rotten eggs. Dapagliflozin is unstable under high temperature and bright light.

Dapagliflozin is mainly used as a pesticide to control various pests, including insects, fungi, and weeds. It can act as an insecticide by blocking the nerve conduction system of pests. Dapagliflozin can also be used as a precursor for explosive substances, such as in the preparation of gunpowder.

The preparation method of dapagliflozin is mainly prepared by methylating nitrourea. Reacting nitroaniline urea with a methylation reagent (such as methine oxide) to obtain N-methylnitroaniline urea. Then, N-methylnitrourea is subjected to nitration reaction, and nitric acid and sulfuric acid are added to nitration it, resulting in the final dapagliflozin product.

-Dapagliflozin is a strong oxidant that should be avoided from contact with flammable materials.

-Maintain good ventilation during operation to avoid inhaling its gas or dust.

-Avoid contact and reaction with strong acids, strong bases, and other substances.

-Dapagliflozin may be toxic to aquatic organisms and should be avoided from being discharged into water sources.

-When using or handling dapagliflozin, appropriate personal protective equipment such as gloves, goggles, and face shields should be worn.

Name (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Synonyms Daglican
BMS-512148
Dapagliflozi
BMS-512148-05
Dapagliflozin
DAPAGLIFLOZIN
DAPAGLIFLOZIN BASE
Dapagliflozin propanediol
Dapagliflozin S1548 Selleck
(1S)-1,5-anhydro-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol
(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
CAS 461432-26-8
EINECS 639-683-0
InChI InChI=1/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
Molecular Formula C21H25ClO6
Molar Mass 408.88
Density 1.349
Melting Point 55-58°C
Boling Point 609.0±55.0 °C(Predicted)
Flash Point 322.139°C
Solubility DMSO : ≥ 100 mg/mL (244.58 mM)
Vapor Presure 0mmHg at 25°C
Appearance White to off-white (Solid)
Color White to Pale Yellow
pKa 13.23±0.70(Predicted)
Storage Condition 2-8°C
Stability Hygroscopic
Refractive Index 1.614

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