Active Pharmaceutical Ingredients

Catalog ID80017403

CAS NO.68359-37-5

Purity 96%

MDL NumberMFCD00078636

EINEC269-855-7

Molecular formula C22H18Cl2FNO3

Molecular weight 434.2876

Melting point: 91~97°C

Aspect	Details
Chemical Properties	– Molecular Formula: C22H18Cl2FNO3<br>- Molecular Weight: 417.29 g/mol
Mechanism of Action	– Cyfluthrin is a synthetic pyrethroid insecticide that delays the closure of sodium channels in nerve cells, leading to prolonged sodium influx and hyperexcitability of the nervous system.<br>- It can also affect neurotransmitter systems, including serotonin (5-HT) and gamma-aminobutyric acid (GABA) pathways.
Pharmacokinetics	– Absorption: Rapidly absorbed in rats when emulsified in Cremophor EL: water solution.<br>- Distribution: Metabolites are widely distributed in tissues, with higher residues in fat and sciatic nerve.<br>- Metabolism: Undergoes ester hydrolysis and oxidation to form various metabolites, including 3-phenoxy-4-fluorobenzoic acid.<br>- Excretion: Metabolites are primarily excreted in urine and feces, with significant interindividual differences.
Toxicity	– Acute Toxicity: Type I and type II pyrethroids, including cyfluthrin, exert their toxic effects by prolonging the open phase of sodium channels, leading to hyperactivity of the nervous system.<br>- Chronic Toxicity: Classified as “not likely to be carcinogenic to humans” by the US EPA.<br>- Environmental Toxicity: Pyrethroids are highly nonpolar, with low water solubility and high affinity for soil and sediment. They are relatively stable in water at neutral pH but susceptible to hydrolysis at higher pH.
Environmental Fate	– Photodegradation: Cyfluthrin in water has a half-life of 0.67 days under sunlight.<br>- Soil Degradation: Half-lives in soil range from 3 to 96 days aerobically and 5 to 430 days anaerobically.<br>- Bioconcentration: In fish, bioconcentration factors (BCF) range from 360 to 6000.
Uses	– Agricultural Pesticide: Used to control a wide range of insect pests in crops.<br>- Public Health: Used in mosquito control programs.

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