Cyclosporin A
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017934
CAS NO.59865-13-3
Purity 98%
MDL NumberMFCD00274558
olecular FormulaC62H111N11O12
Molecular Weight1202.6112
Melting point: 148~151°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C62H111N11O12<br> Molecular weight: 1202.63 g/mol |
| Mechanism of Action | Cyclosporin A is an immunosuppressive agent that inhibits T-cell activation by binding to cyclophilin, forming a complex that inhibits calcineurin. This prevents the transcription of interleukin-2 (IL-2) and other cytokines, reducing immune responses. |
| Therapeutic Uses | Organ Transplantation: Prevents organ rejection in kidney, liver, and heart transplants.<br> Autoimmune Diseases: Used in rheumatoid arthritis, psoriasis, and nephrotic syndrome.<br> Other Indications: Graft-versus-host disease (GVHD), uveitis, and amyotrophic lateral sclerosis (ALS). |
| Formulations | Available as capsules, tablets, and oral solutions. |
| Dosage | Organ Transplant: Initial dose of 14–18 mg/kg orally or 5–6 mg/kg intravenously, followed by maintenance doses of 5–10 mg/kg/day.<br> Rheumatoid Arthritis: 2.5 mg/kg/day, increased to 4 mg/kg/day if needed.<br> Psoriasis: 2.5 mg/kg/day, increased to 4 mg/kg/day if needed. |
| Side Effects | Increased risk of infections, nephrotoxicity, hepatotoxicity, hypertension, hyperkalemia, and neurotoxicity. |
| Safety Information | Monitoring: Regular blood tests, blood pressure monitoring, and kidney function tests.<br> Contraindications: Avoid in combination with certain drugs that may increase toxicity.<br> Cancer Risk: Increased risk of skin cancer and lymphoma. |
| Storage Conditions | Store at room temperature, protect from light and moisture |
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