Cremophor EL
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Category：Pharmaceutical Materials Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS Number: 61791-12-6
Molecular Formula: Not specifically provided (derivative of polyoxyethylene castor oil)
Appearance: Clear yellow viscous liquid
Usage: Widely used as a non-ionic surfactant, solubilizer, and emulsifier in pharmaceutical formulations to enhance drug dissolution and delivery.
| Attribute | Description |
|---|---|
| Name | Cremophor EL |
| CAS Number | 61791-12-6 |
| Chemical Name | Polyoxyethylene Castor Oil Derivative |
| Molecular Structure | <img src=”https://example.com/cremophor-el-structure” /> (Note: Replace with an actual image link) |
| Physical State | Pale yellow paste at room temperature |
| Solubility | Soluble in water (25 mg/mL, requires ultrasonic treatment), ethanol (30 mg/mL) |
| Chemical Nature | Non-ionic surfactant |
| Applications | Widely used as a solubilizer and emulsifier to improve drug dissolution and delivery |
| Biological Activity | In vitro studies show it can increase impedance initially, then decrease, leading to epithelial cell death after prolonged exposure |
| Toxicity | Demonstrates higher cytotoxicity compared to RH40. impairing epithelial viability and monolayer integrity at concentrations of 10-50 mg/mL |
| Stability | Stable in acid, hard water, and inorganic salts; hydrolyzes in strong alkali |
| Transport Conditions | Generally transported at room temperature, but conditions may vary depending on location |
| Storage Conditions | Store at 4°C, away from light to maintain product stability |
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