Cremophor EL
Pharmaceutical Materials 2025-03-02
CAS Number: 61791-12-6
Molecular Formula: Not specifically provided (derivative of polyoxyethylene castor oil)
Appearance: Clear yellow viscous liquid
Usage: Widely used as a non-ionic surfactant, solubilizer, and emulsifier in pharmaceutical formulations to enhance drug dissolution and delivery.
| Attribute | Description |
|---|---|
| Name | Cremophor EL |
| CAS Number | 61791-12-6 |
| Chemical Name | Polyoxyethylene Castor Oil Derivative |
| Molecular Structure | <img src=”https://example.com/cremophor-el-structure” /> (Note: Replace with an actual image link) |
| Physical State | Pale yellow paste at room temperature |
| Solubility | Soluble in water (25 mg/mL, requires ultrasonic treatment), ethanol (30 mg/mL) |
| Chemical Nature | Non-ionic surfactant |
| Applications | Widely used as a solubilizer and emulsifier to improve drug dissolution and delivery |
| Biological Activity | In vitro studies show it can increase impedance initially, then decrease, leading to epithelial cell death after prolonged exposure |
| Toxicity | Demonstrates higher cytotoxicity compared to RH40. impairing epithelial viability and monolayer integrity at concentrations of 10-50 mg/mL |
| Stability | Stable in acid, hard water, and inorganic salts; hydrolyzes in strong alkali |
| Transport Conditions | Generally transported at room temperature, but conditions may vary depending on location |
| Storage Conditions | Store at 4°C, away from light to maintain product stability |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
