Combretastatin A4
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol
Catalog ID100011
CAS NO.117048-59-6
Purity 98%
MDL NumberMFCD03453309
EINEC Molecular FormulaC18H20O5
Molecular Weight316.351
Appearance:Off-white solid,
| Category | Content |
|---|---|
| Higenamine HCl | Supplementary Information |
| Mechanism of Action | Higenamine HCl is a selective β2-adrenergic receptor agonist and a natural LSD1 inhibitor. It activates the PI3K/Akt/Nrf2 signaling pathway, reducing oxidative stress and inflammation. |
| Research Applications | – Cardiovascular Protection: Reduces cardiac and renal fibrosis in rats with cardiorenal syndrome.<br>- Neuroprotection: Mitigates hypoxia-induced brain injury by inducing heme oxygenase-1.<br>- Bone Health: Promotes osteogenesis via the IQGAP1/SMAD4 signaling pathway. |
| Safety and Hazards | – Harmful if swallowed (GHS Classification H302).<br>- Causes serious eye irritation (H319).<br>- Very toxic to aquatic life with long-lasting effects (H410). |
| Storage and Solubility | – Store at -20°C, protect from light.<br>- Soluble in DMSO (65 mg/mL), sonication recommended. |
| Potential Therapeutic Uses | – Investigated for treating heart diseases, osteoporosis, and neurodegenerative disorders.<br>- Studied for its antimycobacterial activity. |
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