Active Pharmaceutical Ingredients

Clotrimazole is a broad-spectrum antifungal drug, which has a good antibacterial effect on a variety of fungi, especially Candida albicans. Its mechanism is to inhibit the synthesis of fungal cell membrane and affect its metabolic process. It has antibacterial effect on superficial fungi and some deep fungi.

Molecular Formula: C22H17ClN2

Molecular Weight:344.8

CAS No.: 23593-75-1

Description

White powder or colorless crystalline powder. Melting point 147-149 ℃. Soluble in absolute ethanol, acetone and chloroform, almost insoluble in water. Odorless and tasteless, it decomposes rapidly in acid solution. Clotrimazole hydrochloride, melting point 159 ℃.

Application

It has broad-spectrum antifungal activity. It has good antibacterial activity against Trichophyton epidermidis, Trichophyton, Aspergillus, coloring fungi, Cryptococcus and Candida. It also has certain antibacterial activity against Sporothrix schenckii, blastoderma dermatitis, coccidiospores and histoplasm..

Packing and Storage

Preserve in tight, light-resistant containers.

Minimum Order

One package

Title	Content
Introduction	Clotrimazole is an antifungal medication belonging to the imidazole class, used primarily to treat various fungal infections of the skin.
Mechanism of Action	Clotrimazole inhibits the biosynthesis of ergosterol in fungal cell membranes by blocking the demethylation of 14-α-lanosterol. This disruption leads to cell membrane instability and fungal cell death.
Medical Uses	– Skin Infections: Athlete’s foot, jock itch, ringworm, and other fungal skin infections.<br>- Vaginal Candidiasis: Used as a topical treatment for yeast infections.<br>- Oral Candidiasis: Oral lozenges are used for local treatment.
Dosage Forms	– Topical Creams, Lotions, Solutions: Applied directly to the affected skin.<br>- Oral Lozenges: For oral fungal infections.<br>- Vaginal Creams: For vaginal yeast infections.
Common Side Effects	– Skin Irritation: Redness, burning, stinging, itching, or peeling at the application site.<br>- Allergic Reactions: Rash, hives, swelling, or difficulty breathing.
Serious Side Effects	– Severe Skin Reactions: Blistering, oozing, or open sores.<br>- Systemic Effects: Rare but may include severe allergic reactions requiring immediate medical attention.
Precautions	– Avoid contact with eyes, nose, mouth, and vagina.<br>- Do not use on broken or irritated skin.<br>- Inform your doctor if you are pregnant, breastfeeding, or using other medications.
Storage Conditions	Store at room temperature, away from heat, moisture, and direct light. Do not freeze.

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