Clindamycin Hydrochloride CAS 21462-39-5
Category：Active Pharmaceutical Ingredients
Introduction
Clindamycin is a semi-synthetic antibiotic with broad antibacterial spectrum and strong antibacterial activity. It has obvious antibacterial activity against Gram-positive bacteria. Clindamycin products currently used in clinical practice include clindamycin hydrochloride, clindamycin phosphate and clindamycin palmitate
Molecular Formula:C18H33ClN2O5S,HCL
Molecular Weight:461.5
CAS No.: 21462-39-5
Description
Clindamycin Hydrochloride is a white or almost white, crystalline powder. It is very soluble in water, slightly soluble in ethanol (96 per cent).
Application
Clindamycin Hydrochloride is a derivative of Lincomycin. Its antimicrobial spectrum is the same as that of Lincomycin, but its antimicrobial activity is strong. Clinically, Clindamycin hydrochloride is mainly used for osteomyelitis, anaerobic bacterial infection, respiratory infection, biliary tract infection, endocarditis, otitis media, skin and soft tissue infection and septicemia.
Packing
25kg/bag or as per customer’s requirements.
Storage
Preserve in airtight containers.
Minimum Order
One package
Clindamycin Hydrochloride: A Veterinary Antibiotic
Clindamycin Hydrochloride is an important antibiotic in veterinary medicine, widely used for treating various bacterial infections in animals.
1. General Characteristics
| Aspect | Details |
| Classification | Lincosamide antibiotic, closely related to clindamycin phosphate and lincomycin. The hydrochloride form is another common salt of clindamycin. |
| Source | Semi – synthetically derived from lincomycin. Similar to clindamycin phosphate, it undergoes chemical modification, in this case, reacting with hydrochloric acid to form the hydrochloride salt. |
| Formulation | Available as powders, which can be formulated into capsules, tablets, and oral suspensions for oral administration. Injectable solutions are also available for parenteral use, allowing for rapid absorption into the bloodstream. Topical preparations such as creams and gels can be used for treating skin infections. |
| Solubility | Soluble in water, which is beneficial for preparing solutions for different routes of administration. This property enables easy preparation of oral and injectable solutions, facilitating drug delivery to animals. |
2. Mechanism of Action
| Action | Explanation |
| Inhibition of Protein Synthesis | Once in the body, clindamycin hydrochloride exerts its effect in a similar way to clindamycin phosphate. It binds to the 50S ribosomal subunit of bacteria. Specifically, it targets the peptidyl transferase region, which is crucial for the formation of peptide bonds during protein synthesis. By binding to this region, it inhibits the elongation of the polypeptide chain. As a result, bacterial protein synthesis is disrupted, leading to growth arrest and eventually cell death. |
| Selective Activity | It has a predominantly Gram – positive antibacterial spectrum. It is highly effective against bacteria such as Staphylococcus spp., including methicillin – resistant Staphylococcus aureus (MRSA) in some cases, Streptococcus spp., and Clostridium spp. It also shows significant activity against many anaerobic bacteria. However, its activity against most Gram – negative bacteria is limited, except for certain species like Bacteroides fragilis. |
3. Clinical Applications and Considerations
| Category | Details |
| Applications | – Treating respiratory tract infections in livestock and poultry. In poultry, it can be used to combat infections caused by Mycoplasma gallisepticum and Staphylococcus aureus. In cattle, it helps manage respiratory diseases caused by Streptococcus spp. – Managing skin and soft – tissue infections in animals. Topical applications are effective against infections caused by Staphylococcus spp. and Streptococcus spp. It can be used to treat wounds, abscesses, and dermatitis in animals. – Treating anaerobic infections in animals. For example, in poultry, it is used to treat necrotic enteritis caused by Clostridium perfringens. In companion animals, it can be used to treat deep – seated infections where anaerobic bacteria are likely involved. – Treating dental infections in dogs and cats. Many oral pathogens, both aerobic and anaerobic, are sensitive to clindamycin hydrochloride, making it useful for treating periodontal disease and oral abscesses. |
| Considerations | – Overuse can contribute to the development of antibiotic – resistant bacteria. Adhering strictly to the dosage and treatment duration prescribed by veterinarians is crucial. – High doses or long – term use may cause gastrointestinal upset in animals. Symptoms can include diarrhea, vomiting, and loss of appetite. In severe cases, it can disrupt the normal gut microbiota, potentially leading to the overgrowth of Clostridium difficile, which can cause severe diarrhea. – Caution is required when using it in combination with other drugs. There may be potential drug – drug interactions, especially with other antibiotics that target protein synthesis, such as macrolides. Since they bind to similar sites on the ribosome, concurrent use may lead to competition and altered antibacterial effects. |
Clindamycin Hydrochloride plays a vital role in maintaining the health and productivity of livestock, poultry, and companion animals by effectively treating a wide range of bacterial infections.
