Active Pharmaceutical Ingredients

Chemical Name: Climbazole

CAS No: 38083-17-9

Assay: ≥99.0%

Appearance: White crystalline powder

Climbazole CAS: 38083-17-9 More Details：

Specification:

Appearance White crystalline powder

Purity ≥99

Melting point (℃) 96-98

P-Chlorophenol ≤0.015

Chloride ≤0.1

Water ≤0.5

Climbazole CAS: 38083-17-9 Usage：

It has broad-spectrum bactericidal properties. It is mainly used for anti itching and anti dandruff conditioning shampoo and hair care shampoo.

It can also be used for antibacterial soap, shower gel, medicated toothpaste, mouthwash, etc

Climbazole CAS: 38083-17-9 Packaging and Shipping：

25kgs/Bag or Drum or as required by buyer.

Climbazole CAS: 38083-17-9 Storage:

Store in a cool, ventilated place, protect from sun, heat and moisture.Storage and transportation according to general chemical regulations.

Item	Content
Introduction	Climbazole (CAS No.: 38083-17-9) is a synthetic imidazole antifungal agent used in pharmaceuticals and cosmetics. It is effective against various fungal infections, particularly those affecting the skin and scalp.
Chemical Properties	– Molecular Formula: C₁₅H₁₇ClN₂O₂<br>- Molecular Weight: 292.76<br>- Appearance: White solid
Mechanism of Action	Climbazole inhibits fungal growth by disrupting the synthesis of ergosterol, a vital component of fungal cell membranes. This leads to increased membrane permeability and cell death.
Applications	– Pharmaceuticals: Used in topical medications for skin infections.<br>- Cosmetics: Key ingredient in anti-dandruff shampoos and scalp treatments.
Safety Profile	– Toxicity: Moderately toxic by ingestion; low toxicity by skin contact.<br>- Usage Guidelines: In rinse-off products (e.g., shampoos), up to 0.5% concentration; in leave-on products, up to 0.2%.
Storage Conditions	– Powder: -20°C for 2 years.<br>- In Solvent: -80°C for 1 year.
Environmental Impact	Climbazole is an emerging recalcitrant contaminant in wastewater, posing severe toxic effects on aquatic organisms.
Synonyms	1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one, Crinipan AD, BAY-E 6975

Names and Identifiers

Name	Climbazole
Synonyms	MEB-6401 Diadimefon Climbazole Crinipan AD BAY MEB-6401 Climbazole 0.1 1-[(4-Chlorophenoxy)(tert-butylcarbonyl)Methyl]iMidazole 1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone 1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one 1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one
CAS	38083-17-9
EINECS	253-775-4
InChI	InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3
InChIKey	OWEGWHBOCFMBLP-UHFFFAOYSA-N

38083-17-9 – Physico-chemical Properties

Molecular Formula	C15H17ClN2O2
Molar Mass	292.76
Density	1.17±0.1 g/cm3(Predicted)
Melting Point	96-100°C
Boling Point	447.5±40.0 °C(Predicted)
Flash Point	224.4°C
Water Solubility	58mg/L at 25℃
Solubility	DMSO : ≥ 47 mg/mL (160.54 mM). Easily soluble in toluene and methanol, hardly soluble in water.
Vapor Presure	0.001Pa at 25℃
Appearance	White to off-white (Solid)
Color	White to Almost white
BRN	618020
pKa	5.66±0.22(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.54
MDL	MFCD00055505
Physical and Chemical Properties	white or off-white crystalline or crystalline powder soluble in toluene and alcohol, insoluble in water
Use	With broad-spectrum bactericidal properties, mainly used for anti-itching and anti-dandruff conditioning shampoo, hair care shampoo, can also be used for antibacterial soap, shower gel, drug toothpaste, Oral Liquid, etc
In vitro study	Climbazole exhibits high anti-Pityrosporum ovale efficacy both in vivo and in vitro, and Pityrosporum ovale may be the main cause of dandruff. The chemical structure and properties of Climbazole are similar to other antifungal agents, such as ketoconazole and miconazole. The MICs of climbazole ranged between <0.06 and 1 μg/mL, with an experimental median of 0.06 μg/mL.
In vivo study	Climbazole is not mutagenic in the Salmonella typhimurium or Escherichia coliAmes test and does not induce micronuclei in human lymphocytes. An in vivo mouse micronucleus test also showed no mutagenicity, with a maximum tolerance dose (MTD) of up to 150 mg/kg administered orally. In an in vitro and in vivo unconventional DNA synthesis assay, climbazole showed no damage to DNA in rat livers when administered orally with MTD up to 200 mg/kg. In mice, [

38083-17-9 – Risk and Safety

Risk Codes	R22 – Harmful if swallowed R50/53 – Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S60 – This material and its container must be disposed of as hazardous waste. S61 – Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077
WGK Germany	3
RTECS	EL7085000
HS Code	29332900

38083-17-9 – Upstream Downstream Industry

Raw Materials

Pyrazole Imidazole

38083-17-9 – Reference Information

LogP	3.83 at 25℃
Use	Gambo is a racemate composed of equimolar amounts of (R)-and (S)-Gambo, IUPAC is named (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl -3, 3-dimethylbut-2-one, it is a topically applied antifungal agent used to treat human fungal skin infections. It can be contained in over-the-counter anti-dandruff shampoo preparations and skin treatment compositions to treat dandruff and eczema caused by fungal infections. Glycol mainly blocks the synthesis of lanosterol 14 α-demethylase (also known as fungal CYP51) in P450 enzymes non-competitively, thereby inhibiting the biosynthesis of ergosterol, an important component of plasma fungal cell membranes, and killing fungal cells. It has broad-spectrum sterilization performance, and is mainly used for antipruritic and dandruff conditioning shampoo, hair care shampoo, and can also be used for antibacterial soap, shower gel, pharmaceutical toothpaste, mouthwash, etc. Shampoo, shower gel, soap
biological activity	Climbazole is a broad-spectrum imidazole antifungal agent with anti-dandruff effect.

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