Ciclesonide
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80018061
CAS NO.126544-47-6
Purity 95%
MDL NumberMFCD00866004
Molecular Formula C32H44O7
Molecular Weight 540.6876
Melting point: 200~207°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C32H44O7<br> Molecular weight: 544.69 |
| Physical Properties | Appearance: White crystalline powder |
| Mechanism of Action | Ciclesonide is a prodrug that is enzymatically hydrolyzed to its active metabolite, des-ciclesonide, in the lungs. Des-ciclesonide has a higher affinity for glucocorticoid receptors compared to the parent compound and exerts potent anti-inflammatory effects. It inhibits the release of inflammatory mediators and suppresses immune responses. |
| Therapeutic Uses | Respiratory Conditions: Used for the treatment of asthma and allergic rhinitis.<br> Formulations: Available as nasal sprays and inhalers for local delivery to the respiratory tract. |
| Pharmacokinetics | Absorption: Negligible oral bioavailability due to low gastrointestinal absorption and high first-pass metabolism.<br> Distribution: Highly bound to plasma proteins, with a large volume of distribution.<br> Metabolism: Metabolized by cytochrome P450 3A4 in the liver.<br> Excretion: Primarily excreted in feces, with minimal renal excretion. |
| Safety Information | Side Effects: May cause nasal bleeding, headache, and respiratory infections.<br> Drug Interactions: Use with caution when co-administered with strong CYP3A4 inhibitors like ketoconazole.<br> Contraindications: Avoid in patients with hypersensitivity to ciclesonide or its components. |
| Storage Conditions | Store at room temperature, protect from light and moisture |
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