Choline Alfoscerate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms sn-Glycero-3-phosphocholine
Catalog ID80019127
CAS NO.28319-77-9
Purity 99%
MDL NumberMFCD00063544
EINEC248-962-2
Molecular FormulaC8H20NO6P
Molecular Weight257.22
Melting point: 118~125°C
| Category | Details |
|---|---|
| Chemical Properties | Choline Alfoscerate (L-α-glycerophosphorylcholine) is a choline-containing phospholipid with the molecular formula C8H20NO6P. It is a white to off-white crystalline powder or granules. |
| Physical Properties | Melting point: 168–172°C. It is highly hygroscopic and can turn sticky when exposed to humid air. |
| Pharmacological Effects | Choline Alfoscerate is used to improve cognitive dysfunction in patients with dementia of neurodegenerative and vascular origin. It is hydrolyzed to choline in the gut, which is a precursor of the neurotransmitter acetylcholine. It has been shown to increase acetylcholine levels in the brain, enhance learning and memory, and improve cognitive, behavioral, and functional outcomes in patients with Alzheimer’s disease and stroke. |
| Mechanism of Action | It acts as a parasympathetic agent by increasing the release and levels of acetylcholine in the brain. It also promotes neuronal differentiation, antagonizes neurotoxicity, and reduces oxidative stress. |
| Pharmacokinetics | It has an elimination half-life of 0.5–6.2 hours. It is completely absorbed following oral administration. |
| Formulations and Administration | Commercially available as soft capsules, typically administered at a dose of 400 mg three times a day. Tablet formulations have also been developed to overcome the disadvantages of soft capsules. |
| Safety and Precautions | Generally well-tolerated, but some studies have reported potential risks such as increased stroke incidence in large cohorts. |
| Storage Conditions | Store in a cool, dry place, protected from moisture |
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