Chemical Additives

Molecular Formula: C17H19ClN2S

HCL Molecular Weight: 355.3

CAS No.: 69-09-0

Names and Identifiers

Name	chloropromazine hydrochloride
Synonyms	CP HEBANIL LARGACTIL KLORPROMEX Chlorpromazine HCL LABOTEST-BB LT00452986 lorproMazine hydrochloride ChlorpoMazine Hydrochloride Chlorpromazine hydrochloride chloropromazine hydrochloride Chlorpromazine Hydrochloride (200 mg) ChlorproMazine hydrochloride(Largactil) 2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE HCL 2-CHLORO-10-[3′-(DIMETHYLAMINO)PROPYL]PHENOTHIAZINE, HCL 2-CHLORO-N,N-DIMETHYL-10H-PHENOTHIAZINE-10-PROPANAMINE, HCL 2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE HYDROCHLORIDE 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine 2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride 2-Chloro-N,N-diMethyl-10H-phenothiazine-10-propanaMine Hydrochloride [3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-dimethylamine hydrochloride Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil
CAS	69-09-0
EINECS	200-701-3
InChI	InChI=1/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

69-09-0 – Physico-chemical Properties

Molecular Formula	C17H20Cl2N2S
Molar Mass	355.33
Density	1.2221 (estimate)
Melting Point	192-196°C
Flash Point	9℃
Water Solubility	>=10 g/100 mL at 24 ºC
Solubility	DMSO 71 mg/mL Water 71 mg/mL Ethanol 71 mg/mL
Appearance	Powder/Solution
Color	White to off-white or clear colorless
Merck	14,2185
BRN	3779989
PH	pH (50g/L, 25℃) : 4.0～5.0
Storage Condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Air and light sesnsitive.
Sensitive	Sensitive to light and humidity
MDL	MFCD00012654
Physical and Chemical Properties	melting point 192-196°C water-soluble> = 10g/100 mL at 24°C White or opalescent crystalline powder. Melting point 179-180 °c (194-196 °c). Soluble in water, ethanol, chloroform, insoluble in ether, benzene. With hygroscopicity, 5% aqueous solution with pH value of 4-5. Slightly odorous, extremely bitter. This product is easy to oxidize, in the air or sunlight gradient to red-brown.dangerous goods Mark T + risk category code 25-26 safety instructions 28-36/37-45 dangerous goods transport number UN 2811 6.1/PG 1 WGK Germany 3 RTECS SO1750000 F 3-10-21 Hazard Class 6.1 (B) PackingGroup III customs code 29173980
Use	This product is a representative drug in the drug of the drug. On the central nervous system, small doses have a stabilizing effect, large doses of continuous use of antipsychotic effect, this product inhibits the hypothalamus temperature regulation center, so that the body temperature with the ambient temperature rise and fall, with other drugs, to reduce the body temperature to normal body temperature, decreased metabolism, called artificial hibernation. It is mainly used for antipsychotics, strengthening the role of hypnotics, anesthetics, analgesics and anticonvulsants. And can be used for the Vomit and intractable hiccup of vomiting and cause artificial hibernation.
In vitro study	Chlorpromazine affects microipsc (mIPSCs) by decreasing binding (Kon) and increasing binding disengagement (Koff) of GABAARs. Chlorpromazine regulates the activation of the TRPA1 current in a potential-dependent manner, resulting in an increase in the probability of blocking at positive potentials and opening at negative potentials.
In vivo study	Chlorpromazine down-regulates various T-cell-derived lymphokines (IL-2,IFN-γ,IL-4, tumor necrosis factor, and GM-CSF) independently the generation and upregulation of IL-10 secretion in an in vivo model of acute superantigen-driven immune activation. Chlorpromazine mediates SEB-driven Chlorpromazin secretion, accompanied by an enhanced accumulation of IL-10 mRNA. Chlorpromazine protects against lethality in mice, normal or adrenal and guinea pigs against LPS and suppresses serum levels of tumor necrosis factor. When administered 30 minutes before LPS induction, at the same time, or 10 minutes after PS induction, Chlorpromazine prevents lipopolysaccharide lethality, administration after 30 minutes of LPS induction is ineffective. In actinomycin D-induced sensitized LPS mice, Chlorpromazine significantly inhibited the lethality and hepatotoxicity of LPS. Chlorpromazine protects brain tissue from anoxia-induced irreversible loss of synaptic transmission in rats. In) rats, Chlorpromazine also significantly delayed the onset of hypoxia-induced diffuse depression.

69-09-0 – Risk and Safety

Risk Codes	R25 – Toxic if swallowed R26 – Very Toxic by inhalation R39/23/24/25 – R23/24/25 – Toxic by inhalation, in contact with skin and if swallowed. R11 – Highly Flammable
Safety Description	S28 – After contact with skin, wash immediately with plenty of soap-suds. S36/37 – Wear suitable protective clothing and gloves. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 – Keep away from sources of ignition.
UN IDs	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	SO1750000
FLUKA BRAND F CODES	3-10-21
TSCA	Yes
HS Code	29173980
Hazard Class	6.1(b)
Packing Group	III
Toxicity	LD50 orally in rats: 225 mg/kg (Goldenthal)

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