Chlormadinone acetate
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80018016
CAS NO.302-22-7
Purity 98+%
MDL NumberMFCD00056471
EINEC206-118-0
Molecular formula C23H29ClO4
Molecular weight 404.927
Melting point: 211~215°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C23H29ClO4<br> Molecular weight: 404.9 g/mol |
| Physical Properties | Appearance: White crystalline powder |
| Mechanism of Action | Chlormadinone acetate is a synthetic progestogen with anti-androgenic properties. It acts by binding to progesterone receptors and blocking androgen receptors in target organs. It reduces the activity of skin 5α-reductase and suppresses gonadotropin secretion, thereby inhibiting ovulation. |
| Therapeutic Uses | Contraception: Used in combination with estrogen as an oral contraceptive.<br> Other Uses: Historically used for threatened abortion and dysmenorrhea. |
| Pharmacokinetics | Rapid and almost complete absorption after oral administration. Steady state reached by day 7 with peak plasma concentrations around 2 ng/mL. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture. |
| Safety Information | Side Effects: Commonly reported side effects include breakthrough bleeding, spotting, and amenorrhea.<br> Contraindications: Not used in the United States or the United Kingdom since 1970. |
| Synonyms | Gestafortin, Menstridyl, Normenon, Matrol, Cero |
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