Active Pharmaceutical Ingredients

Catalog ID80018016

CAS NO.302-22-7

Purity 98+%

MDL NumberMFCD00056471

EINEC206-118-0

Molecular formula C23H29ClO4

Molecular weight 404.927

Melting point: 211~215°C

Category	Details
Chemical Properties	Molecular formula: C23H29ClO4<br> Molecular weight: 404.9 g/mol
Physical Properties	Appearance: White crystalline powder
Mechanism of Action	Chlormadinone acetate is a synthetic progestogen with anti-androgenic properties. It acts by binding to progesterone receptors and blocking androgen receptors in target organs. It reduces the activity of skin 5α-reductase and suppresses gonadotropin secretion, thereby inhibiting ovulation.
Therapeutic Uses	Contraception: Used in combination with estrogen as an oral contraceptive.<br> Other Uses: Historically used for threatened abortion and dysmenorrhea.
Pharmacokinetics	Rapid and almost complete absorption after oral administration. Steady state reached by day 7 with peak plasma concentrations around 2 ng/mL.
Storage Conditions	Store in a cool, dry place, protected from light and moisture.
Safety Information	Side Effects: Commonly reported side effects include breakthrough bleeding, spotting, and amenorrhea.<br> Contraindications: Not used in the United States or the United Kingdom since 1970.
Synonyms	Gestafortin, Menstridyl, Normenon, Matrol, Cero

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