Cefuroxime Sodium CAS 56238-63-2
Category：Active Pharmaceutical Ingredients
Introduction
Molecular Formula： C16H15N4NaO8S
Molecular Weight： 446.37
CAS No.: 56238-63-2
It is a semi-synthetic second-generation cephalosporin. Its activity against gram-positive bacteria (including penicillin-resistant golden grapes) is similar to that of the first-generation cephalosporin, and its effect on gram-negative bacteria is stronger than that of the first-generation cephalosporin.
Description
It is a white or almost white, slightly hygroscopic powder. It is freely soluble in water, very slightly soluble in ethanol (96 per cent).
Application
It is suitable for the treatment of infections caused by sensitive bacteria. Lower respiratory tract infections: such as acute bronchitis and acute exacerbation of chronic bronchitis and pneumonia. Upper respiratory tract infections: including ear, nose, and throat infections such as otitis media, sinusitis, tonsillitis, and pharyngitis. Genitourinary tract infections: such as pyelonephritis, cystitis and urethritis. Skin and soft tissue infections: such as rickets, pyoderma and impetigo. Treatment of early Lyme disease in adults and children over 12 years of age, and subsequent prevention of advanced Lyme disease. Gonorrhea: acute uncomplicated gonococcal urethritis and cervicitis.
Packing
25kg/bag or as per customer’s requirements.
Storage
Preserve in an airtight container, protected from light. If the substance is sterile, store in a sterile, airtight, tamper-proof container.
Minimum Order
One package
Cefuroxime Sodium: A Veterinary Antibiotic
Cefuroxime Sodium is an important antibiotic in veterinary medicine, used for treating various bacterial infections in animals.
1. General Characteristics
| Aspect | Details |
| Classification | Second – generation cephalosporin antibiotic. Cephalosporins are a class of beta – lactam antibiotics with a distinct chemical structure compared to penicillins. |
| Source | Synthesized through chemical processes. It is derived from 7 – aminocephalosporanic acid, with specific side – chain modifications to confer its antibacterial properties and pharmacokinetic profile. |
| Formulation | Available as powders, which can be formulated into injectable solutions for parenteral use, allowing for rapid delivery of the drug into the bloodstream. In some cases, it may be used in topical formulations for treating skin and soft – tissue infections, although injectable use is more common for systemic infections. |
| Solubility | Soluble in water, which is beneficial for preparing solutions for injection. This property enables easy reconstitution of the powder into a suitable solution for administration to animals. |
2. Mechanism of Action
| Action | Explanation |
| Inhibition of Cell Wall Synthesis | Cefuroxime Sodium, like other beta – lactam antibiotics, binds to and inactivates penicillin – binding proteins (PBPs) in bacteria. These proteins are responsible for the cross – linking of peptidoglycan chains in the bacterial cell wall. By blocking this cross – linking process, the cell wall becomes weakened. As the bacteria grow and divide, the weakened cell wall cannot withstand the internal osmotic pressure, leading to cell lysis and death. |
| Selective Activity | It has a broad – spectrum antibacterial effect. Against Gram – positive bacteria, it is effective against Staphylococcus spp. (including some methicillin – resistant strains to a certain extent), Streptococcus spp., and Clostridium spp. Among Gram – negative bacteria, it is active against Escherichia coli, Proteus spp., Haemophilus influenzae, and Neisseria spp. The second – generation cephalosporins, such as cefuroxime sodium, have enhanced activity against Gram – negative bacteria compared to first – generation cephalosporins. |
3. Clinical Applications and Considerations
| Category | Details |
| Applications | – Treating respiratory tract infections in livestock and poultry. In poultry, it can be used against Escherichia coli, Pasteurella multocida, and streptococcal infections. In cattle, it helps combat respiratory diseases caused by Mannheimia haemolytica and Pasteurella multocida. – Managing urinary tract infections in dogs and cats. It can target Escherichia coli and other common urinary tract pathogens. – Treating skin and soft – tissue infections in animals, often caused by Staphylococcus spp. and Streptococcus spp. – In some cases, used to treat postoperative infections in animals, as it can effectively target a wide range of potential pathogens. |
| Considerations | – Overuse can lead to the development of antibiotic – resistant bacteria. Adhering to proper dosage and treatment duration as prescribed by veterinarians is crucial. – Allergic reactions can occur in some animals, similar to other beta – lactam antibiotics. Symptoms may include rash, itching, swelling, and in severe cases, anaphylaxis. Monitoring for allergic reactions after administration is important. – High doses or long – term use may cause gastrointestinal upset in animals, including diarrhea, vomiting, and loss of appetite. It may also disrupt the normal gut microbiota. – Caution is required when using it in combination with other drugs. There may be potential drug – drug interactions, especially with other antibiotics that target cell wall synthesis or drugs that affect the renal function. For example, when used with aminoglycosides, there may be an increased risk of nephrotoxicity. |
Cefuroxime Sodium plays a significant role in maintaining the health and productivity of livestock, poultry, and companion animals by effectively treating a wide range of bacterial infections.
