What Are The Main Applications of 3,5-Difluorochlorobenzene CAS No.:1435-43-4?
FAQ 2025-04-11 215
3,5-Difluorochlorobenzene (CAS No. 1435-43-4) is a versatile compound with significant applications in pharmaceuticals, agrochemicals, and organic synthesis. 1. Pharmaceutical Intermediate Serves as a critical building block for the synthesis of drug molecules, hormones, and bioactive compounds. Its fluorinated and chlorinated aromatic structure provides unique reactivity and pharmacokinetic properties, making it valuable in drug discovery and d
What Is 2-Chloro-4,5-difluorobenzoic Acid Used For？
FAQ 2025-04-11 471
2-Chloro-4,5-difluorobenzoic acid (CAS No. 110877-64-0) is primarily utilized as an intermediate in pharmaceutical and agrochemical synthesis. Its key applications include: Pharmaceuticals: Antibacterial Agents: It serves as a crucial building block for synthesizing novel antibacterial drugs, particularly in the fluoropyridone carboxylic acid class, which exhibits broad-spectrum antimicrobial activity. Cardiovascular Medications: The compound i
In which field is LCZ696 Intermediate used the most?
FAQ 2025-04-11 186
LCZ696 Intermediate is predominantly used in the pharmaceutical industry, particularly in the synthesis of LCZ696 (Entresto®), a medication for heart failure. LCZ696, a dual-acting angiotensin receptor-neprilysin inhibitor (ARNI), combines sacubitril and valsartan to treat heart failure with reduced ejection fraction (HFrEF) and hypertension. Its intermediate is critical for the following reasons: Drug Synthesis: LCZ696 Intermediate serves as a
What is the difference between LCZ696 Intermediate II CAS No.:1012341-48-8 and LCZ696 Intermediate N-3 (CAS No.: 1012341-50-2)?
FAQ 2025-04-11 191
1. Chemical Structures and Properties LCZ696 Intermediate II (CAS No.: 1012341-48-8): Chemical Name: (R,E)-5-([1,1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid Molecular Formula: C₂₃H₂₇NO₄ Molecular Weight: 381.46 g/mol Function: Acts as a key intermediate in the synthesis of LCZ696, contributing to the formation of the active pharmaceutical ingredient (API). LCZ696 Intermediate N-3 (CAS No.: 1012341-50-2):
Is LCZ696 Intermediate N-3 (CAS No.: 1012341-50-2) Harmful to Humans?
FAQ 2025-04-11 191
LCZ696 Intermediate N-3 (CAS No.: 1012341-50-2) is a chemical intermediate primarily used in pharmaceutical synthesis, particularly in the production of sacubitril/valsartan (Entresto®), a medication for heart failure. While specific toxicity data for this intermediate may not be widely published in open sources, general principles of chemical safety and risk assessment can be applied based on its classification and intended use. 1. Chemical Clas
What is 2-Bromo-4-fluoroaniline?
FAQ 2025-04-11 237
2-Bromo-4-fluoroaniline (CAS No.: 1003-98-1) 1. Basic Information Chemical Name: 2-Bromo-4-fluoroaniline Synonyms: 2-Bromo-4-fluoro-phenylamine, 4-Fluoro-2-bromoaniline CAS Number: 1003-98-1 Molecular Formula: C₆H₅BrFN Molecular Weight: 190.01 g/mol Physical State: Transparent yellow-to-brown liquid Melting Point: 41 °C Boiling Point: 221 °C (760 mmHg) Density: 1.67 g/cm³ (25 °C) Flash Point: 104.4 °C Solubility: Partially miscible in water; sol
What Is 2-Fluoroiodobenzene Used For?
FAQ 2025-04-10 221
2-Fluoroiodobenzene (CAS No. 348-52-7) is a halogenated aromatic compound with the molecular formula C₆H₄FI. It is widely utilized in organic synthesis and pharmaceutical research due to its unique reactivity and versatility. 1. Pharmaceutical Intermediates Synthesis of Active Pharmaceutical Ingredients (APIs): 2-Fluoroiodobenzene serves as a crucial intermediate in the production of pharmaceuticals, particularly in the development of drugs targ
What Is 2,5-Dibromo-1,3-Dichlorobenzene Uesd For?
FAQ 2025-04-10 187
2,5-Dibromo-1,3-dichlorobenzene (CAS No. 19393-97-6) is a halogenated aromatic compound with the molecular formula C₆H₂Br₂Cl₂. It is widely used in various industrial and research applications due to its unique chemical properties. 1. Pharmaceutical Intermediate Synthesis of Active Pharmaceutical Ingredients (APIs): 2,5-Dibromo-1,3-dichlorobenzene serves as a key intermediate in the production of pharmaceuticals, particularly in the development
What is 2 5 dihydroxycinnamic acid methyl ester?
FAQ 2025-04-10 197
2,5-Dihydroxycinnamic acid methyl ester, also known as Methyl 2,5-dihydroxycinnamate, is a chemical compound with the molecular formula C₁₀H₁₀O₄ and a molecular weight of approximately 194.18 g/mol. It is a derivative of cinnamic acid, featuring a methyl ester group and two hydroxyl groups at the 2 and 5 positions of the phenyl ring. Properties Appearance: Typically exists as a yellow crystalline solid. Melting Point: Ranges from 178°C to 180°C.
What Is 2,2′-Azobis(2-methylpropionamidine) dihydrochloride CAS No.:2997-92-4 Used For?
FAQ 2025-04-10 185
2,2′-Azobis(2-methylpropionamidine) dihydrochloride (CAS No. 2997-92-4) is a chemical compound primarily used as a free radical initiator in polymerization reactions and biochemical research. Polymerization Initiator: Serves as an efficient initiator for the polymerization of acrylic, vinyl, and allylic monomers, enabling the synthesis of polymers with controlled molecular weights and structures. Particularly effective in aqueous solution
Why is cabazitaxel better than docetaxel?
FAQ 2025-04-10 213
Cabazitaxel is not universally “better” than docetaxel; rather, its superiority depends on specific clinical contexts, patient characteristics, and treatment histories. 1. Efficacy in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Cabazitaxel: Second-Line Therapy: Approved for mCRPC after progression on docetaxel. Clinical trials (e.g., TROPIC) demonstrated improved overall survival (OS) and progression-free survival (PFS)
What type of chemotherapy is cabazitaxel?
FAQ 2025-04-10 213
Cabazitaxel is classified as a microtubule inhibitor and belongs to the taxane class of chemotherapy agents. Mechanism of Action: Cabazitaxel disrupts cell division by binding to tubulin, the protein subunit of microtubules. This binding stabilizes microtubules, preventing their depolymerization (breakdown) during mitosis. As a result, cancer cells are unable to complete cell division, leading to cell cycle arrest and apoptosis (programmed cell d
