Caspofungin acetate CAS NO.:179463-17-3
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS NO.:179463-17-3
Molecular formula:C54H92N10O17
Molecular weight:1153.38
Standard：enterprise standard
Content：≥98.0%
Packaging:100G/BAG
Use to:Antifungal agen
Micafungin Sodium: An Antifungal Agent
Micafungin sodium is an important antifungal drug used in the treatment of various fungal infections.
1. General Information
| Aspect | Details |
| Classification | Echinocandin antifungal |
| Source | Produced by fermentation of a strain of Glarea lozoyensis |
| Administration | Intravenous infusion |
| Formulation | Available as a lyophilized powder for reconstitution |
2. Mechanism of Action
| Action | Explanation |
| Inhibition of Cell Wall Synthesis | Micafungin sodium specifically targets 1.3 – β – D – glucan synthase, an enzyme essential for the synthesis of 1.3 – β – D – glucan in the fungal cell wall. By inhibiting this enzyme, it disrupts the formation of the fungal cell wall. |
| Disruption of Cell Integrity | The lack of proper 1.3 – β – D – glucan in the cell wall leads to osmotic instability and ultimately cell lysis and death of the fungus. |
3. Clinical Applications
| Indication | Details |
| Candidiasis | Effective in treating esophageal candidiasis, invasive candidiasis, and candidemia. It is often used as an alternative to traditional antifungal agents, especially in cases where there is resistance or intolerance to other drugs. |
| Prophylaxis in Hematopoietic Stem Cell Transplantation | Given to patients undergoing hematopoietic stem cell transplantation to prevent invasive fungal infections, mainly caused by Candida species. |
4. Adverse Effects
| Side Effect | Frequency |
| Gastrointestinal Effects | Nausea, vomiting, and diarrhea are relatively common, occurring in a small percentage of patients. |
| Allergic Reactions | Rarely, patients may experience allergic reactions such as rash, pruritus, and in severe cases, anaphylaxis. |
| Laboratory Abnormalities | Elevations in liver enzymes (alanine aminotransferase, aspartate aminotransferase) may be observed, which usually require monitoring during treatment. |
In conclusion, micafungin sodium offers a valuable option for treating and preventing fungal infections, with a generally acceptable safety profile.
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