Active Pharmaceutical Ingredients

Molecular Formula: C26H28Cl2N4O4

Molecular Weight: 531.4

CAS No.: 65277-42-1

Product name:Ketoconazole

It is an imidazole broad-spectrum antifungal drug, which is mainly used to treat and prevent various infections caused by Malassezia, such as tinea versicolor, seborrheic dermatitis and scalp pityriasis (dandruff), and can quickly alleviate scaling and itching caused by seborrheic dermatitis and scalp pityriasis.

Description

This product is off white crystalline powder; Odorless and tasteless. It is easily soluble in chloroform, soluble in methanol, slightly soluble in ethanol, and almost insoluble in water.

Application

Infections of skin, hair and fingers (toes) caused by dermatophytes and / or yeasts (dermatomycosis, onychomycosis, candidal periodontitis, tinea versicolor, pityriasis capitis folliculitis and chronic cutaneous mucosal candidiasis, etc.) can be treated with this product when local treatment is ineffective or cannot be used due to infection site, area, depth and other factors.

Packing and Storage

Preserve in well-closed containers.

Minimum Order

One package

Title	Content
Introduction	Ketoconazole (CAS 65277-42-1) is a broad-spectrum antifungal medication used to treat various fungal infections, including superficial and systemic mycoses. It is available in oral and topical formulations.
Chemical Properties	– Molecular Formula: C₂₆H₂₈Cl₂N₄O₄<br>- Molecular Weight: 531.43<br>- Appearance: White to almost white crystalline powder.<br>- Melting Point: 146°C.<br>- Solubility: Insoluble in water.
Mechanism of Action	Ketoconazole inhibits the enzyme lanosterol 14α-demethylase (CYP51A1), which is essential for the synthesis of ergosterol in fungal cell membranes. This disruption leads to fungal cell death.
Medical Uses	– Superficial Infections: Effective for skin and nail infections caused by dermatophytes, yeasts, and molds.<br>- Systemic Infections: Used to treat serious fungal infections like candidiasis, aspergillosis, and histoplasmosis.<br>- Other Uses: Investigated for treating endogenous Cushing’s syndrome and certain dermatological conditions.
Dosage Forms	– Oral Tablets: Commonly used for systemic infections.<br>- Topical Creams/Gels: Applied directly to the skin for localized infections.
Common Side Effects	– Gastrointestinal: Nausea, vomiting, abdominal pain.<br>- Hepatotoxicity: Potential liver damage, especially with prolonged use.<br>- Endocrine: May affect adrenal function.<br>- Skin: Rash, itching.
Serious Side Effects	– Liver Damage: Severe hepatotoxicity can occur, potentially leading to liver failure.<br>- Adrenal Insufficiency: Risk of adrenal suppression, particularly with high doses.
Precautions	– Monitor liver function regularly, especially during long-term treatment.<br>- Avoid in patients with severe liver disease.<br>- Use with caution in patients with adrenal insufficiency.<br>- Inform your doctor about other medications to avoid interactions.
Storage Conditions	Store at 2-8°C, protect from heat and moisture.

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