Active Pharmaceutical Ingredients

Molecular Formula: C25H44N14O8

Molecular Weight: 668.71

CAS No.: 1405-37-4

Description

It is a white or almost white powder. It is very soluble in water, practically insoluble in chloroform, in ethanol (96%) and in ether.

Application

It is suitable for second-line treatment for tuberculosis, treatment failure of first-line anti-tuberculosis drugs (such as streptomycin, isoniazid, rifampicin and ethambutol), or one or more of the above drugs When producing toxic effects or bacterial resistance.

Packing and Storage

Preserve in airtight containers.

Minimum Order

One package

Item	Content
Introduction	Capreomycin Sulphate is a polypeptide antibiotic used primarily in the treatment of multidrug-resistant tuberculosis (MDR-TB). It is a second-line drug that inhibits protein synthesis in Mycobacterium tuberculosis by binding to the 70S ribosomal unit.
Mechanism of Action	Capreomycin Sulphate binds to the 70S ribosomal unit of Mycobacterium tuberculosis, inhibiting protein synthesis and thus preventing bacterial growth.
Medical Uses	– Multidrug-Resistant Tuberculosis (MDR-TB): Used in combination with other drugs.<br>- Research: Studied for its anti-amyloidogenic and pro-fibrinolytic activities, with potential applications in Alzheimer’s disease and Parkinson’s disease.
Dosage Forms	– Injection: Administered intramuscularly or intravenously.<br>- Powder for Inhalation: Investigated for use in inhalation therapy.
Common Side Effects	– Nephrotoxicity: Elevated blood urea nitrogen (BUN), decreased creatinine clearance, proteinuria.<br>- Ototoxicity: Hearing loss, tinnitus, vestibular dysfunction.<br>- Other: Headache, fatigue, respiratory infections.
Serious Side Effects	– Severe Nephrotoxicity: Significant kidney damage requiring dose adjustment or discontinuation.<br>- Permanent Hearing Loss: Risk of irreversible ototoxicity.<br>- Neuromuscular Blockade: Potential for respiratory paralysis.
Precautions	– Renal Function Monitoring: Regular renal function tests are required.<br>- Hearing Tests: Regular hearing assessments to detect ototoxicity.<br>- Avoid Concomitant Use: Do not use with other nephrotoxic or ototoxic drugs.<br>- Special Populations: Caution in elderly patients and those with renal impairment.<br>- Pregnancy and Breastfeeding: Use with caution; potential risk to the fetus.
Storage Conditions	Store at -20°C for powder; in solvent, store at -80°C.
Contraindications	– Hypersensitivity to Capreomycin.<br>- Severe renal impairment.<br>- Pregnancy and breastfeeding unless benefits outweigh risks.
Interactions	– Increased Toxicity: With aminoglycosides, amphotericin B, vancomycin, and other nephrotoxic or ototoxic drugs.<br>- Masking Symptoms: Antihistamines and phenothiazines may mask ototoxic symptoms.

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