Butenafine hydrochloride
Active Pharmaceutical Ingredients 2025-03-03
English Synonyms Butenafine HCl 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine,hydrochloride Catalog ID100340
CAS NO.101827-46-7
Purity98%
MDL NumberMFCD00917064
EINEColecular FormulaC23H27N.HCl
Molecular Weight353.934
Appearance:Off-white powder
Melting point:210-214°C
Boiling point:426.1℃ at 760 mmHg
Flash point:187.7°C”
| Category | Content |
|---|---|
| Generic Name | Butenafine Hydrochloride |
| Brand Name | Lotrimin Ultra, Mentax, etc. |
| Chemical Formula | C23H28ClN3O.HCl |
| Mechanism of Action | Butenafine is a benzylamine antifungal that inhibits squalene epoxidase, an enzyme involved in fungal cell membrane sterol synthesis. This leads to the accumulation of toxic squalene and depletion of ergosterol, causing fungal cell death. |
| Indications | – Treatment of various fungal skin infections, including athlete’s foot, jock itch, ringworm, and pityriasis versicolor.<br>- Not recommended for fungal nail infections. |
| Dosage Forms | Cream, gel, spray, and solution for topical use. |
| Administration | – Apply a thin layer to the affected area once or twice daily, as directed.<br>- Treatment duration varies by infection type, typically 1 to 4 weeks. |
| Side Effects | Common side effects include burning, itching, redness, dryness, flaking, or worsening of symptoms at the application site. |
| Precautions | – For external use only; avoid contact with eyes, mouth, and mucous membranes.<br>- Not recommended for children under 12 years unless prescribed by a doctor.<br>- Do not use on broken or scraped skin. |
| Storage | Store at room temperature (20° to 25°C) and protect from moisture. |
| Developer | Developed by various pharmaceutical companies. |
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