Bupivacaine HCl CAS NO.14252-80-3
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017817
CAS NO.14252-80-3
Purity 99%
MDL NumberMFCD00078956
Molecular FormulaC18H28N2O.HCl
Molecular Weight324.8887
Melting point: 258.5°C
| Aspect | Details |
|---|---|
| Mechanism of Action | Bupivacaine HCl is an amide-type local anesthetic that blocks voltage-gated sodium channels in nerve cells, preventing the initiation and conduction of nerve impulses. |
| Indications | Used in adults for local or regional anesthesia or analgesia for surgery, dental procedures, diagnostic and therapeutic procedures, and obstetrical procedures. |
| Contraindications | Contraindicated in obstetrical paracervical block anesthesia, intravenous regional anesthesia (Bier Block), and in patients with known hypersensitivity to bupivacaine or other amide-type local anesthetics. |
| Administration | Administered via infiltration, perineural, or retrobulbar injection. Specific concentrations and dosages vary based on the type of block required. |
| Adverse Effects | Common side effects include dizziness, drowsiness, hypotension, and cardiac arrest (especially in obstetrical anesthesia). Other serious adverse reactions include methemoglobinemia and chondrolysis. |
| Precautions | Monitor cardiovascular and respiratory vital signs after injection. Avoid rapid injection of large volumes and use fractional doses when feasible. |
| Storage Conditions | Store at controlled room temperature (15° to 30°C). Protect from light. |
| Special Populations | Use in pediatric patients under 12 years is not recommended. Elderly patients and those with hypertension may be at increased risk for hypotension. |
| Overdose Risks | Overdose can lead to systemic toxicity, including seizures and cardiac arrhythmias. Immediate medical intervention is required |
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