Bosentan hydrate

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Category:Active Pharmaceutical Ingredients   Own Brand:MT  /MOQ:100KG  /From China/  B2B only.

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Introduction

Catalog ID80071731

CAS NO.157212-55-0

Purity 99%

MDL NumberMFCD09751188

Molecular FormulaC27H29N5O7S.H2O

Molecular Weight569.63

Melting point: 111~113°C

Category Details
Chemical Name Bosentan Hydrate
Other Names Ro 47-0203. N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2.2′-bipyrimidin]-4-yl]-4-(1.1-dimethylethyl)benzenesulfonamide hydrate
CAS Number 157212-55-0
Molecular Formula C27H31N5O7S
Molecular Weight 573.63 g/mol (hydrate form)
Appearance Reddish-brown to off-white solid
Indications
  • Pulmonary arterial hypertension (PAH)
  • Improvement of exercise capacity and hemodynamic parameters
Mechanism of Action
  • Endothelin receptor antagonist
  • Blocks the actions of endothelin-1 (ET-1) on ETA and ETB receptors
  • Leads to vasodilation and decreased pulmonary vascular resistance
Dosage Form Tablets
Strength Various strengths available (e.g., 62.5 mg, 125 mg)
Administration Oral, usually twice daily
Side Effects
  • Headache, flushing, dizziness
  • Liver function abnormalities, anemia
  • Edema, nausea, vomiting

(Note: The incidence and severity of side effects may vary)

Contraindications
  • Hypersensitivity to bosentan or any component of the formulation
  • Moderate to severe hepatic impairment
  • Pregnancy and lactation
Precautions
  • Monitor liver function regularly
  • Use with caution in patients with mild hepatic impairment
  • Not recommended for use in children or adolescents below 18 years of age
Storage Store at room temperature, protected from moisture and light

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