Boc-NH-PEG2-Tos CAS NO.: 206265-94-3
Biomedicine 2025-03-04
CAS NO.: 206265-94-3
Product purity: ≥95%
Molecular formula: C18H29NO7S
Molecular weight: 403.49
Product Usage: Used in medical research, drug release, nanotechnology and new material research, cell culture. As well as in ligand research, peptide synthesis support, grafted polymer compounds, new materials and polyethylene glycol modified functional coatings and other active compounds.
Basic Information
| Item | Description |
|---|---|
| Full Name | Boc-NH-PEG2-Tos (Tosyl-PEG2-NH-Boc) |
| CAS Number | 192132-77-7 |
| Molecular Formula | C16H25NO6S |
| Molecular Weight | 359.44 |
| Purity | ≥95% |
| Appearance | White to off-white solid |
| Solubility | Soluble in water, DMSO, DMF, DCM |
| Storage Conditions | -20°C, dry, protected from light |
Detailed Information
| Item | Description |
|---|---|
| Structure | Contains a Boc-protected amine group, a PEG chain with two ethylene oxide units, and a tosylate (Tos) group |
| Reactivity | – The Boc group can be deprotected under mild acidic conditions to form a free amine.<br>- The tosylate group is a good leaving group for nucleophilic substitution reactions |
| Applications | – PROTAC Synthesis: Used as a linker in the synthesis of PROTACs (Proteolysis Targeting Chimeras) for selective protein degradation.<br>- Bioconjugation: Modifies proteins, peptides, and other biomolecules to improve stability and reduce immunogenicity.<br>- Drug Delivery: Enhances drug stability and targeting.<br>- Surface Modification: Improves biocompatibility of nanoparticles and other materials. |
| Advantages | High biocompatibility, good water solubility, and versatile reactivity |
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