Boc-NH-PEG2-CH2COOH CAS NO.:108466-89-3
Pharmaceutical Materials 2025-03-02
Catalog ID:10852
CAS NO.:108466-89-3
Purity:≥95%
Molecular Weight:263.3
Appearance: Colorless to light yellow liquid
Boc-NH-PEG2-CH2COOH is a versatile compound widely used in biochemical and pharmaceutical applications. It is a PEG (polyethylene glycol) derivative with a Boc (tert-butoxycarbonyl) protected amino group and a carboxylic acid functionality at the other end. This unique structure makes it an ideal linker for PROTAC (proteolysis-targeting chimera) synthesis, enabling the selective degradation of target proteins via the ubiquitin-proteasome system. Its good solubility in water and polar solvents, along with its biocompatibility, make it a valuable intermediate in the modification of proteins and peptides.
| Property | Details |
|---|---|
| CAS Number | 108466-89-3 |
| Chemical Name | Boc-NH-PEG2-CH2COOH |
| Molecular Formula | C11H21NO6 |
| Molecular Weight | 263.29 g/mol |
| Appearance | Viscous liquid |
| Boiling Point | 630.4°C at 760 mmHg |
| Melting Point | 240°C |
| Density | N/A (Predicted: 1.145±0.06 g/cm³) |
| Solubility | Soluble in water and polar solvents |
| Stability | Stable under normal conditions, Boc group can be removed under acidic conditions |
| Uses | PROTAC linker, intermediate in biochemical and pharmaceutical synthesis |
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