Agrochemicals

Blasticidin S

Chemical Name: 1-[(4-Amino-1,2-dihydro-2-oxopyrimidin-1-yl)-1,3,4,5,6-pentahydroxyhexyl]-3-[3-(4-amino-4,6-dideoxy-β-D-glucopyranosyloxy)propyl]guanidine
Synonyms: Bla-S; NSC 56353
CAS Number: 2079-00-7
Molecular Formula: C₁₇H₂₆N₈O₅
Molecular Weight: 422.45 g/mol

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Physical & Chemical Properties

Property	Specification
Appearance	White crystalline powder (hydrochloride salt common)
Solubility	Soluble in water (50 mg/mL), methanol; insoluble in organic solvents
Melting Point	253-255°C (dec.)
Optical Rotation	[α]²⁵D +108° (c=1, H₂O)
pKa	2.3, 8.9 (basic groups)
UV λmax	274 nm (water)

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Biological Activity

• Mode of Action: Protein synthesis inhibitor (binds 50S ribosomal subunit)
• Target Organisms:

• Antifungal (especially Pyricularia oryzae)
• Antibacterial (Gram-positive)
• Mammalian cells (toxic above 10 μg/mL)
  • IC₅₀: 0.1-1 μM (fungal cells)

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Hazard & Safety Information (GHS)

Warning Symbols:
⚠️ Acute Toxicity (Category 3)
⚠️ Eye Damage (Category 1)

Hazard Codes:
• H301: Toxic if swallowed
• H318: Causes serious eye damage
• H335: May cause respiratory irritation

Precautionary Measures:
• P261: Avoid breathing dust
• P280: Wear gloves/eye protection
• P301+P310: IF SWALLOWED: Call poison center

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Applications

✔ Agricultural Fungicide: Rice blast control (limited use due to toxicity)
✔ Selection Marker: In cell biology (with resistance gene bsr)
✔ Research Tool: Eukaryotic translation studies

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